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Daniel Western

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Articles by Daniel Western

Author Correction: Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases - Nature Medicine

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By Muhammad Shoaib Ali, Buddhiprabha Erabadda, Yike Chen, Ying Xu, Katherine Gong, Menghan Liu, Daniel Western, Chengran Yang, Gyujin Heo, Jacob Vogel, Betty M. Tijms, Farhad Imam, Oskar Hansson
| Nature Verified
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03833-1, published online 15 July 2025. This article was originally published under standard Springer Nature license (© The Author(s), under exclusive licence to Springer Nature America, Inc.). It is now available as an open-access paper under a Creative Commons Attribution 4.0 International license, © The Author(s). The error has been corrected in the HTML and PDF versions of the article.
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Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases - Nature Medicine

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By Muhammad Shoaib Ali, Buddhiprabha Erabadda, Yike Chen, Ying Xu, Katherine Gong, Menghan Liu, Daniel Western, Chengran Yang, Gyujin Heo, Jacob Vogel, Betty M. Tijms, Farhad Imam, Oskar Hansson
| Nature Verified
Abstract Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and frontotemporal dementia (FTD), exhibit distinct yet overlapping pathological mechanisms.
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Disruption of the cerebrospinal fluid–plasma protein balance in cognitive impairment and aging - Nature Medicine

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By Amelia Farinas, Daniel Western, Kathryn Lawrence, Hamilton OH, Andy P. Tsai, Yann Le Guen, Stephen Montgomery, David Baker, Kathleen L. Poston, Anthony Wagner, Carlos Cruchaga, Veronica Augustina Bot, Seonghyun Yoon
| Nature Verified
Abstract The brain barrier system, including the choroid plexus, meninges and brain vasculature, regulates substrate transport and maintains differential protein concentrations between blood and cerebrospinal fluid (CSF). Aging and neurodegeneration disrupt brain barrier function, but proteomic studies of the effects on blood–CSF protein balance are limited.
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A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease - Nature Medicine

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By Hamilton OH, Linda Karlsson, Michael Duggan, Nader Morshed, Chengran Yang, Daniel Western, Muhammad Shoaib Ali, Yann Le Guen, Anssi Lipponen, Kathleen L. Poston, Anthony Wagner, Edward Wilson, Rebecca Gottesman, Josef Coresh, Keenan A. Walker, Henrik Zetterberg, Nicolai Franzmeier, Oskar Hansson, Carlos Cruchaga
| Nature Verified
Abstract Rates of cognitive decline in Alzheimer’s disease (AD) are extremely heterogeneous. Although biomarkers for amyloid-beta (Aβ) and tau proteins, the hallmark AD pathologies, have improved pathology-based diagnosis, they explain only 20–40% of the variance in AD-related cognitive impairment (CI). To discover novel biomarkers of CI in AD, we performed cerebrospinal fluid (CSF) proteomics on 3,397 individuals from six major prospective AD case–control cohorts.
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Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum

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By Muhammad Sufyan Ali, Jigyasha Timsina, Daniel Western, Menghan Liu, Aleksandra Beric, John Budde, Anh Do Verified, Gyujin Heo, Lihua Wang, Suzanne Schindler, John Morris, David M. Holtzman, Agustín Ruiz, Ignacio Álvarez, Miquel Aguilar, Jen Gentsch
| Cell Press Verified
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Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits - Nature Genetics

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By Ciyang Wang, Chengran Yang, Daniel Western, Muhammad Shoaib Ali, Yueyao Wang, John Budde, Agustín Ruiz, Maria Fernandez, María Fernández, Daniel J. Panyard, Yuetiva Deming, Mercè Boada, Pablo García-González, Richard Perrin, Yun Ju Sung
| Nature Verified
Abstract Brain metabolism perturbation can contribute to traits and diseases. We conducted a genome-wide association study for cerebrospinal fluid (CSF) and brain metabolite levels, identifying 205 independent associations (47.3% new signals, containing 11 new loci) for 139 CSF metabolites, and 32 independent associations (43.8% new signals, containing 4 new loci) for 31 brain metabolites.
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Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer’s disease | Nature Genetics

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By Daniel Western, Chengran Yang, Bridget Phillips, Yueyao Wang, Muhammad Shoaib Ali, Aleksandra Beric, Pat Kohlfeld, John Budde, Allan Levey, Richard Perrin, Agustín Ruiz, Jarod Rutledge, Hamilton OH, Edward Wilson, Yann Le Guen, Lianne M. Reus, Betty M. Tijms, Charlotte Teunissen, Ignacio Álvarez, Tony Wyss-Coray, Yun Ju Sung, Ciyang Wang, David J. Pulford
| Nature Verified
Abstract The integration of quantitative trait loci (QTLs) with disease genome-wide association studies (GWASs) has proven successful in prioritizing candidate genes at disease-associated loci. QTL mapping has been focused on multi-tissue expression QTLs or plasma protein QTLs (pQTLs). We generated a cerebrospinal fluid (CSF) pQTL atlas by measuring 6,361 proteins in 3,506 samples.
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Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease - npj Parkinson's Disease

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By Chengran Yang, Ignacio Álvarez, Suzanne Schindler, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustín Ruiz, Joel S. Perlmutter, Richard Perrin, Yun Ju Sung, Bridget Phillips, Daniel Western, Raquel Puerta
| Nature Verified
Abstract Common and rare variants in the LRRK2 locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remain unknown. We performed comprehensive proteogenomic analyses using the largest aptamer-based CSF proteomics study to date (7006 aptamers (6138 unique proteins) in 3107 individuals).
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