Danielle Elizabeth Robson

1 What Is the Definition of RPL and Who Should Be Investigated? Pregnancy loss is defined as the spontaneous loss of a pregnancy before the fetus reaches viability. Recurrent pregnancy loss (RPL) is defined as two or more losses before 20 weeks of gestation [1]. Around 5% of women will experience two pregnancy losses [2]. After two losses, it is advisable for women to seek evaluation by a qualified medical practitioner, as some causes of RPL can be treated [1, 3]. 2 What Can Cause RPL?

1 What Is Recurrent Pregnancy Loss? Recurrent pregnancy loss (RPL) is when a woman experiences two or more pregnancy losses before 20 weeks of pregnancy. It is relatively uncommon, affecting about 5% of women/couples. After two miscarriages, it is recommended that women seek medical advice as some causes of RPL can be treated. 2 What Can Cause RPL?

THROMBOPHILIA Thrombophilias can be inherited (congenital) or acquired (Table 1). Congenital thrombophilias are associated with an increased risk of thromboembolism, yet available evidence related to recurrent pregnancy loss (RPL) is inconclusive. In comparison, acquired thrombophilias are associated with RPL.