Loading metrics Open Access Peer-reviewed Research Article Citation: Shaw CL, Kennedy DA (2025) Early epidemiological characteristics explain the chance of population-level virus persistence following spillover events. PLoS Biol 23(8): e3003315. https://doi.org/10.1371/journal.pbio.3003315 Academic Editor: Jason T. Ladner, Northern Arizona University, UNITED STATES OF AMERICA Received: January 15, 2025; Accepted: July 14, 2025; Published: August 21, 2025 Copyright: © 2025 Shaw, Kennedy.