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De-Li Shi on Muck Rack

De-Li Shi

As seen in: Wiley Online Library, Frontiers, MDPI, BioRxiv, Cell Press, HAL, The Journal of Biological Chemistry
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Articles

Prkra dimer senses double-stranded RNAs to dictate global translation efficiency

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By Tong Lu, Pengcheng Ma, Hailing Fang, Aijun Chen, Jianlin Xu, Xi Kuang, Mingyu Wang, Ling Su, Sen Wang, Yizhuang Zhang, Jiasheng Wang, Boya Yang, De-Li Shi, Yong Zhou, Qianqian Gong, Xiangguo Liu, Bingyu Mao, Ming Shao
| Cell Press Verified
Keywords double-stranded RNA Prkra PACT/RAX dsRNA sensor translation initiation early embryos embryonic stem cells Introduction Double-stranded RNAs (dsRNAs) are evolutionarily conserved pathogen-associated molecular patterns that frequently accumulate during viral infections due to viral genome replication.1,2,3 They act as stress stimuli that trigger an integrated stress response (ISR) characterized by a global inhibition of translation.4,5,6 This response is initiated by the activation of...
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Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation

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By Liangqing Zhang, De-Li Shi, Lili Yu, Simeng Li
| BioRxiv
Abstract Myocardial ischemia-reperfusion (IR) injury is the most common type of heart disease. IR-disrupted mitochondrial homeostasis affects heart energy metabolism and function, but the mechanism remains poorly understood. Here we report a cardioprotective role of the mitochondrial protein Sirt5 in a mouse model of cardiac IR injury. The down-regulation of Sirt5 in IR-injured heart is associated with an increased protein lactylation and impaired mitochondrial function.
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Knockout of rbm24a and rbm24b genes in zebrafish impairs skeletal and cardiac muscle integrity and function during development

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By Audrey Saquet, De-Li Shi, Raphaëlle Grifone, Ziwei Ying
| Wiley Online Library Verified
1 INTRODUCTION RNA-binding proteins (RBPs) are critical regulators of gene expression in a wide variety of cell types from embryogenesis to adulthood.
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