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Delaram Rahbarinia on Muck Rack

Delaram Rahbarinia

As seen in: Cell Press
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Articles

The landscape of structural variation in pediatric cancer

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By Robert Greenhalgh, Samuel Brady, Wentao Yang, Diane A. Flasch, Michael Edmonson, Nadezhda V. Terekhanova, Yanling Liu, Jian Wang, Karol Szlachta, Liqing Tian, Daniel K. Putnam, Delaram Rahbarinia, Pandurang Kolekar, Xin Zhou, Daniela S. Gerhard, Xiaotu Ma, Jinghui Zhang
| Cell Press Verified
Keywords pediatric cancer cancer genomics structural variation RAG-mediated recombination resource cancer evolution signatures Introduction Structural variants (SVs) occur during the rearrangement of genomic segments, such as through intra-chromosomal deletions, duplications, inversions, or inter-chromosomal translocations,1 and those acquired somatically can promote tumorigenesis via multiple mechanisms.2,3,4,5,6 Historically, SVs in the form of chromosomal rearrangements were detected by...
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