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DENFREE Thailand

As seen in: Nature
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By Waradon Sungnak, Tiraput Poonpanichakul, Natnicha Jiravejchakul, Damita Jevapatarakul, Narita Thungsatianpun, Lisa M Dratva, Lorenz Kretschmer, DENFREE Thailand, Oranart Matangkasombut, Gavin Screaton, Wanwisa Dejnirattisai, Thaneeya Duangchinda, Jongeun Park, Kerstin B Meyer, Juthathip Mongkolsapaya, Varodom Charoensawan, Sarah A Teichmann, Ponpan Matangkasombut, Sirawit Srikor, Chawinya Trakoolsoontorn, Anunya Opasawatchai
| Nature Verified
Abstract Dengue virus (DENV) is a major global health threat, with secondary heterotypic infections potentially inducing detrimental memory immune responses. Antigen-specific CD8 + T cells contribute to both protection and pathogenicity, yet how their phenotypic heterogeneity relates to disease severity remains unclear. Here, we performed plate-based single-cell RNA sequencing of circulating DENV-specific CD8 + T cells identified by HLA tetramers loaded with DENV NS3-derived epitopes.
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Cytokine and chemokine kinetics in natural human dengue infection as predictors of disease outcome - Scientific Reports

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By DENFREE Thailand
| Nature Verified
Abstract Dengue is an important tropical disease with considerable global impact. Despite this, there remains an urgent need for reliable biomarkers to predict disease severity, as well as effective antiviral drugs and targeted treatments. In this study, we conducted a comprehensive profiling of 41 plasma mediators in patients with asymptomatic dengue (AD) and symptomatic dengue (SD), which includes mild dengue fever (DF) and severe dengue hemorrhagic fever (DHF).
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