Ponpan Matangkasombut on Muck Rack

Ponpan Matangkasombut

As seen in: Nature
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By Waradon Sungnak, Tiraput Poonpanichakul, Natnicha Jiravejchakul, Damita Jevapatarakul, Narita Thungsatianpun, Lisa M Dratva, Lorenz Kretschmer, DENFREE Thailand, Oranart Matangkasombut, Gavin Screaton, Wanwisa Dejnirattisai, Thaneeya Duangchinda, Jongeun Park, Kerstin B Meyer, Juthathip Mongkolsapaya, Varodom Charoensawan, Sarah A Teichmann, Ponpan Matangkasombut, Sirawit Srikor, Chawinya Trakoolsoontorn, Anunya Opasawatchai
| Nature Verified
Abstract Dengue virus (DENV) is a major global health threat, with secondary heterotypic infections potentially inducing detrimental memory immune responses. Antigen-specific CD8 + T cells contribute to both protection and pathogenicity, yet how their phenotypic heterogeneity relates to disease severity remains unclear. Here, we performed plate-based single-cell RNA sequencing of circulating DENV-specific CD8 + T cells identified by HLA tetramers loaded with DENV NS3-derived epitopes.
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