Varodom Charoensawan on Muck Rack

Varodom Charoensawan

As seen in: Nature, PLOS ONE
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Articles

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By Waradon Sungnak, Tiraput Poonpanichakul, Natnicha Jiravejchakul, Damita Jevapatarakul, Narita Thungsatianpun, Lisa M Dratva, Lorenz Kretschmer, DENFREE Thailand, Oranart Matangkasombut, Gavin Screaton, Wanwisa Dejnirattisai, Thaneeya Duangchinda, Jongeun Park, Kerstin B Meyer, Juthathip Mongkolsapaya, Varodom Charoensawan, Sarah A Teichmann, Ponpan Matangkasombut, Sirawit Srikor, Chawinya Trakoolsoontorn, Anunya Opasawatchai
| Nature Verified
Abstract Dengue virus (DENV) is a major global health threat, with secondary heterotypic infections potentially inducing detrimental memory immune responses. Antigen-specific CD8 + T cells contribute to both protection and pathogenicity, yet how their phenotypic heterogeneity relates to disease severity remains unclear. Here, we performed plate-based single-cell RNA sequencing of circulating DENV-specific CD8 + T cells identified by HLA tetramers loaded with DENV NS3-derived epitopes.
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Understanding and mitigating the impact of ambient mRNA contamination in single-cell RNA-sequencing analysis

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By Louisa K. James, Varodom Charoensawan, Siriraj Genomics, Jantarika Kumar Arora
| PLOS ONE
Loading metrics Open Access Peer-reviewed Research Article Citation: Arora JK, James LK, Charoensawan V (2025) Understanding and mitigating the impact of ambient mRNA contamination in single-cell RNA-sequencing analysis. PLoS One 20(9): e0332440. https://doi.org/10.1371/journal.pone.0332440 Editor: Wan-Tien Chiang, Augusta University, TAIWAN Received: August 6, 2024; Accepted: August 30, 2025; Published: September 24, 2025 Copyright: © 2025 Arora et al.
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Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells - Nature Communications

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By Masaki Tajima, Toshio Kitamura, Masahiro Kawashima, Masakazu Toi, Koji Yamanoi, Junzo Hamanishi, Varodom Charoensawan, Dean Thumkeo
| Nature Verified
Abstract While prostaglandin E2 (PGE2) is produced in human tumor microenvironment (TME), its role therein remains poorly understood. Here, we examine this issue by comparative single-cell RNA sequencing of immune cells infiltrating human cancers and syngeneic tumors in female mice.
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