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Articles by Derek Morris
Exploration of the genetic neuroinflammatory environment in the human midcingulate cortex in Huntington’s disease
Abstract Despite progress, the pathophysiology involving neuroinflammation in Huntington’s disease remains uncertain, and the genetic environment of the midcingulate cortex in the disease has not been investigated.
An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia | Schizophrenia
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Abstract Symptom severity in schizophrenia has been repeatedly associated with thinner cortical gray matter. While global and regional white matter microstructure alterations in schizophrenia are well-documented, their association with clinical symptom severity remains unclear. As this is likely due to methodological heterogeneity across studies, we tested whether symptom severity in schizophrenia was associated with regional and global white matter alterations using standardized methods.
By Laurena Holleran, Ingrid Agartz, Ole A. Andreassen, Nerisa Banaj, Dara M. Cannon, Aiden Corvin, Melissa Green, Ruben C. Gur, Ryota Hashimoto, Elliot Hong, Cyril Höschl, Peter Kochunov, Stephen M Lawrie, Colm McDonald, Derek Morris, David Mothersill, Christos Pantelis, Fabrizio Piras, David R. Roalf, Theodore D. Satterthwaite, Ulrich Schall, Kang Hee Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Sophia I. Thomopoulos, David Tomecek, Andrew Zalesky, Paul Thompson, Neda Jahanshad, Jessica Turner, Theo van Erp, Gary Donohoe, Aoife Warren, Emma Neilson, Paul E. Rasser
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Nature
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Relevance of polymorphisms in TLR2/4 genes and their association with plasma cytokines for schizophrenia - Genes & Immunity
Abstract Schizophrenia is associated with altered levels of plasma cytokines. Toll-like receptors (TLRs) can be responsible for cytokine synthesis. It remains unclear whether genetic changes in TLRs, e.g. single-nucleotide polymorphisms (SNPs), account for altered levels. Here, we investigate the relationship between SNPs in TLR2 and TLR4 genes, cytokine levels, and cognition. This study included 281 participants (190 controls and 91 schizophrenia patients).
The Dynamic Nature of Genetic Risk for Schizophrenia Within Genes Regulated by FOXP1 During Neurodevelopment
Abstract FOXP1 (Forkhead-box protein P1) is a crucial transcription factor in neural development and is associated with schizophrenia (SCZ). FOXP1-regulated genes may contribute to genetic risk of SCZ and this may vary across different stages of neurodevelopment.
Early life stress, low-grade systemic inflammation and weaker suppression of the default mode network (DMN) during face processing in Schizophrenia - Translational Psychiatry
Study participants Two hundred and twenty-nine participants took part in this study. Fifty three individuals with SZ or SZA were recruited for the Immune Response and Social Cognition (iRELATE) project, as described in our previous studies (King et al., 2021). Briefly, all participants were recruited in Galway and Dublin through community mental health services.
Sons and daughters of encouragement — Derek J. Morris | Ministry Magazine Podcast | Episode
All audio, artwork, episode descriptions and notes are property of Derek J. Morris, for Ministry Magazine Podcast, and published with permission by Transistor, Inc. Broadcast by
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia - Nature Genetics
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Abstract We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We find an excess of ultra-rare protein-truncating variants (PTVs) in patients with BD among genes under strong evolutionary constraint in both major BD subtypes.
By Duncan Palmer, Daniel P. Howrigan, Sinéad B. Chapman, Douglas H. Blackwood, Chia-Yen Chen, David Curtis, Nelson B. Freimer, Fernando S. Goes, Ian Jones, Lisa Jones, René S. Kahn, Mikael Landén, Adam E. Locke, Andrew McIntosh, Andrew Mcintosh, Andrew McQuillin, Derek Morris, Michael O’Donovan, Roel A. Ophoff, Michael Owen, Danielle Posthuma, Andreas Reif, Catherine A. Schaefer, Laura Scott, Tarjinder Singh, Jordan W. Smoller, Weiqing Wang, Benjamin M. Neale
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Nature
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Genetic variants associated with longitudinal changes in brain structure across the lifespan - Nature Neuroscience
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Abstract Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan.
By Rachel M. Brouwer, Katrina Grasby, Hugo G. Schnack, Neda Jahanshad, Emma Sprooten, William S. Kremen, Dag Alnæs, Eric Artiges, Gareth Barker, Erlend Bøen, Isabella A. Breukelaar, Robin Bülow, Dara M. Cannon, Christienne Damatac, Sylvane Desrivières, Covadonga M Díaz-Caneja, Juliane H. Fröhner, Janik Goltermann, Mathew A. Harris, Philip R Jansen, Tianye Jia, Jiyang Jiang, Daniel Keeser, Vicente Medel, Catherine Morgan, Thomas W. Mühleisen, Leila Nabulsi, Bronwyn Overs, Tiago Reis Marques, Gennady V Roshchupkin, Nikita Setiaman, Diana Tordesillas-Gutiérrez, Joanna M. Wardlaw, Wei Wen, Katharina Wittfeld, Gail Davies, Gary Donohoe, Jouke-Jan Hottenga, Maria J. Knol, Stephanie Le Hellard, Karen A. Mather, Yuri Milaneschi, Derek Morris, Markus M Nöthen, Sergi Papiol, Marcella Rietschel, Marcos L Santoro, Jason Stein Verified, Fabian Streit, Alexander Teumer, Evangelos Vassos, Javier Vázquez-Bourgon, Stephanie Witt, Katrin Amunts, Ole A. Andreassen, Celso Arango, Tobias Banaschewski, Sintia I. Belangero, Dorret I. Boomsma, Henry Brodaty, Jan Buitelaar, Sven Cichon, Simon Cox, Udo Dannlowski, Torbjørn Elvsåshagen, Simon E. Fisher, Janice M. Fullerton, Hugh Garavan, Penny Gowland, Hans J. Grabe, Tim Hahn Verified, Andreas Heinz, Manon H.J. Hillegers, Jacqueline Hoare, Mohammad A. Ikram, Andrea Jackowski, René S. Kahn, Mayuresh Korgaonkar, Colm McDonald, Ryan L Muetzel, Robin Murray, Jaap Oosterlaan, Perminder S Sachdev, Gunter Schumann, Philip Shaw, Kang Hee Sim, Dan Stein, Julian Trollor, Jan H. Veldink, Henrik Walter, Margaret Wright, Sarah E. Medland, Barbara Franke, Axel Krug, Ulrik F. Malt, Jean-Luc Martinot, Frauke Nees, Roel A. Ophoff, Peter R. Schofield, Michael N. Smolka, Lars T. Westlye
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Nature
Verified
Utopia or dystopia: how can agencies navigate the brave new world?
Utopia or dystopia: how can agencies navigate the brave new world? In an age of increasing unrest and want for change, are we heading towards utopia or dystopia? And what are the threats and opportunities of this brave new world for us as individuals, as agencies and as a society at large? At the IPA Members’ Lunch on 18th April, man of the moment Jamie Bartlett will enlighten us.
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