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Articles by Derrick Bennett
Analyses of plasma protein levels in relation to body composition in the UK Biobank
Abstract Excess fat mass is causally linked to multiple diseases, but the use of existing therapies, such as glucagon-like peptide-1 receptor agonists, is limited by varying effects and common side effects, including loss of fat-free mass. We aimed to identify proteins associated with fat mass, but ideally not also associated with fat-free mass, as potential drug targets for alternative therapeutic strategies.
Analyses of plasma protein levels in relation to body composition in the UK Biobank
Abstract Excess fat mass is causally linked to multiple diseases, but the use of existing therapies, such as glucagon-like peptide-1 receptor agonists, is limited by varying effects and common side effects, including loss of fat-free mass. We aimed to identify proteins associated with fat mass, but ideally not also associated with fat-free mass, as potential drug targets for alternative therapeutic strategies.
Atlas of genetic architecture and exploratory temporal interaction networks of plasma protein-based organ and system aging
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Abstract Organ-level investigations provide insights into inter-individual heterogeneity in health and disease, yet aging across organs and systems remains incompletely understood.
By Fan Pu, Xueqing Jia, Xiaoxi Hu, Youheng Wu, Yanjie Zhao, Jiening Yu, Shuming Wang, Shuhui Wu, Shenghan Wang, Yishan Wang, Zhiyong Zhao, Dan Wu, Nan Liu, Junfang Chen, Xiaofeng Wang, Juulia Jylhävä, Chiara Herzog, Alan Cohen, Huaidong Du, Derrick Bennett, Robin G Walters, Canqing Yu, Jun Lv, Zhengming Chen, Li Jin, Dianjianyi Sun, Zixin Hu, Zuyun Liu, Ciyun Zhao, Duoduo Fu, Dianqing Chen
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Nature
Verified
Associations of 6600 SomaScan proteins with demographic, lifestyle, environmental and health characteristics in Chinese adults
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Abbreviations AKR1D1: 3-Oxo-5-beta-steroid 4-dehydrogenase ALT: Alanine aminotransferase ANML: Adaptive normalisation by maximum likelihood ANTR2: Anthrax toxin receptor 2 APOF: Apolipoprotein F BGN: Biglycan BMI: Body mass index BPSA: Benign prostatic-specific antigen C1QTNF1: C1q and tumor necrosis factor related protein 1 C1QTNF3: C1q and tumor necrosis factor related protein 3 CFHR5: Complement factor H-related 5 CILP2: Cartilage intermediate layer protein 2 CKB: China Kadoorie biobank...
By Jonathan Clarke, Maria G. Kakkoura, Andri Iona, Baihan Wang, Charlotte Clarke, Neil Wright, Pang Yao, Mohsen Mazidi, Pek Kei Im, Maryam Rahmati, Christiana Kartsonaki, Sam Morris, Hannah Fry Verified, Iona Y. Millwood, Robin G Walters, Yiping Chen, Huaidong Du, Dan Schmidt, Yongmei Liu, Canqing Yu, Dianjianyi Sun, Jun Lv, Michael Hill, Robert Clarke, Derrick Bennett, Zhengming Chen, Maxim Barnard
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Nature
Verified
Incorporation of Patient and Public Involvement in Statistical Methodology Research: Summary of Workshop Proceedings
1 Introduction Patient and Public Involvement (PPI) is defined by the National Institute for Health and Care Research (NIHR) as research being carried out “with” or “by” members of the public rather than “to,” “about,” or “for” them [1]. The benefits of PPI to healthcare research are well-recognized, and include increasing quality, relevance, and impact through expert knowledge of specific health conditions or health system interactions [2, 3].
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults - Nature Communications
Abstract Proteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured plasma levels of 2168 proteins in 3976 Chinese adults using both Olink Explore and SomaScan platforms. The correlation of protein levels between platforms was modest (median rho = 0.29), with protein abundance and data quality parameters being key factors influencing correlation.
Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank - Nature Cardiovascular Research
Abstract Several large-scale studies have measured plasma levels of the proteome in individuals with cardiovascular diseases (CVDs)1,2,3,4,5,6,7. However, since the majority of such proteins are interrelated2, it is difficult for observational studies to distinguish which proteins are likely to be of etiological relevance.
Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations - Nature Medicine
Abstract Circulating plasma proteins play key roles in human health and can potentially be used to measure biological age, allowing risk prediction for age-related diseases, multimorbidity and mortality. Here we developed a proteomic age clock in the UK Biobank (n = 45,441) using a proteomic platform comprising 2,897 plasma proteins and explored its utility to predict major disease morbidity and mortality in diverse populations.
Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults - Nature Communications
Abstract Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations.
Author Correction: Self-supervised learning of accelerometer data provides new insights for sleep and its association with mortality - npj Digital Medicine
Correction to: npj Digital Medicine https://doi.org/10.1038/s41746-024-01065-0, published online 20 May 2024 In this Article the authors have corrected a data cleaning issue. Specifically, some devices (older version of Actigraph) used to collect the wrist-worn accelerometer data for the study could enter sleep mode when the movement detected was low. Based on this, they filtered out the data affected by the sleep mode, only considering data without discontinuity in the data stream.
Self-supervised learning of accelerometer data provides new insights for sleep and its association with mortality - npj Digital Medicine
Abstract Sleep is essential to life. Accurate measurement and classification of sleep/wake and sleep stages is important in clinical studies for sleep disorder diagnoses and in the interpretation of data from consumer devices for monitoring physical and mental well-being. Existing non-polysomnography sleep classification techniques mainly rely on heuristic methods developed in relatively small cohorts.
The burden of neurological conditions in north Africa and the Middle East, 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019 - The Lancet Global Health
Summary The burden of neurological conditions in north Africa and the Middle East is increasing. We aimed to assess the changes in the burden of neurological conditions in this super-region to aid with future decision making.
Iron Status and Risk of Heart Disease, Stroke, and Diabetes: A Mendelian Randomization Study in European Adults
Nonstandard Abbreviations and Acronyms CMD cardiometabolic diseases GRS genetic risk score IS ischemic stroke LAGE localized average causal effects MR Mendelian randomization PheWAS phenome‐wide associations T2D type 2 diabetes TIBC total iron binding capacity TSAT transferrin saturation UKB UK Biobank What Is New?
Long-term solid fuel use and risks of major eye diseases in China: A population-based cohort study of 486,532 adults
Loading metrics Open Access Peer-reviewed Research Article Ka Hung Chan, Mingshu Yan, Derrick A. Bennett, Yu Guo, Yiping Chen, Ling Yang, Jun Lv, Canqing Yu, Pei Pei, Yan Lu, Liming Li , Huaidong Du , Kin Bong Hubert Lam , Zhengming Chen , on behalf of the China Kadoorie Biobank Study group Ka Hung Chan, Mingshu Yan, Derrick A.
Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5 million Chinese adults
Huaidong Du,1,2,* Liming Li,3,4,* Derrick Bennett,2 Yu Guo,4 Iain Turnbull,2 Ling Yang,1,2 Fiona Bragg,2 Zheng Bian,4 Yiping Chen,1,2 Junshi Chen,5 Iona Y. Millwood,1,2 Sam Sansome,2 Liangcai Ma,6 Ying Huang,7 Ningmei Zhang,8 Xiangyang Zheng,9 Qiang Sun,10 Timothy J.
Socioeconomic differences in health-care use and outcomes for stroke and ischaemic heart disease in China during 2009-16: a prospective cohort study of 0·5 million adults - The Lancet Global Health
Summary Background China initiated major health-care reforms in 2009 aiming to provide universal health care for all by 2020. However, little is known about trends in health-care use and health outcomes across different socioeconomic groups in the past decade. Methods We used data from the China Kadoorie Biobank (CKB), a nationwide prospective cohort study of adults aged 30–79 years in 2004–08, in ten regions (five urban, five rural) in China.
Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults
Epidemiology/Health Services Research Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults Derrick A Bennett1, Huaidong Du1,2, Fiona Bragg1, Yu Guo3, Neil Wright1, Ling Yang1,2, Zheng Bian3, Yiping Chen1,2, Canqing YU4, Sisi Wang5, Fanwen Meng5, Jun Lv4, Junshi Chen6, Liming Li3,4, Robert Clarke1, Zhengming Chen1,2 on behalf of the China Kadoorie Biobank Study Collaborative Group 1 Clinical Trial Service Unit and...
Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults
Observational studies have reported that higher plasma 25-hydroxyvitamin D (25[OH]D) concentrations are associated with lower risks of diabetes, but it is unclear if these associations are causal. The aim of this study was to test the relevance of 25(OH)D for type 2 diabetes using genetically instrumented differences in plasma 25(OH)D concentrations.
Mendelian randomisation in cardiovascular research: an introduction for clinicians
Identification of efficacious therapies in large-scale randomised controlled clinical trials (RCTs) have contributed to the reduction of cardiovascular disease (CVD).1 2 However, despite these advances, CVDs (such as ischaemic heart disease and stroke) have persisted in being the leading causes of premature death3 and disability worldwide in 2015.4 Well-designed and conducted RCTs provide the most reliable evidence for efficacy of therapeutic interventions and by extension on the causal role...
Mendelian randomisation in cardiovascular research: an introduction for clinicians
Identification of efficacious therapies in large-scale randomised controlled clinical trials (RCTs) have contributed to the reduction of cardiovascular disease (CVD).1 2 However, despite these advances, CVDs (such as ischaemic heart disease and stroke) have persisted in being the leading causes of premature death3 and disability worldwide in 2015.4 Well-designed and conducted RCTs provide the most reliable evidence for efficacy of therapeutic interventions and by extension on the causal role...
Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5 million Chinese adults
Despite the well-recognised health benefits of fresh fruit consumption, substantial uncertainties remain about its potential effects on incident diabetes and, among those with diabetes, on risks of death and major vascular complications. Between June 2004 and July 2008, the nationwide China Kadoorie Biobank study recruited 0.5 million adults aged 30–79 (mean 51) y from ten diverse localities across China.
A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults
Background: Lipoprotein-associated phospholipase A (Lp-PLA ) has been implicated in development of atherosclerosis; however, recent randomized trials of Lp-PLA inhibition reported no beneficial effects on vascular diseases. In East Asians, a loss-of-function variant in the PLA2G7 gene can be used to assess the effects of genetically determined lower Lp-PLA .
Improving Adherence to Secondary Stroke Prevention Strategies Through Motivational Interviewing
Background and Purpose—Stroke recurrence rates are high (20%–25%) and have not declined over past 3 decades. This study tested effectiveness of motivational interviewing (MI) for reducing stroke recurrence, measured by improving adherence to recommended medication and lifestyle changes compared with usual care.
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