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Articles by Dian Yang
Lineage identity governs oncogene dependence in mouse NSCLC models of KRAS inhibitor resistance
Abstract Primary and acquired resistance to targeted therapy represent significant challenges to durable treatment responses in oncology. In lung adenocarcinoma, KRAS inhibitors are hampered by incomplete clinical responses and acquired resistance. Here we treated genetically engineered mouse models of Kras-driven lung adenocarcinoma with KRAS inhibitors to model these conditions.
Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis
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Abstract Tumor progression is driven by dynamic interactions between cancer cells and their surrounding microenvironment. Here we integrate high-resolution spatial transcriptomics and evolving lineage-tracing technologies to elucidate how tumor expansion, plasticity and metastasis co-evolve with microenvironmental remodeling in a Kras;Trp53-driven mouse model of lung adenocarcinoma.
By Matthew Jones, Dawei Sun, William Colgan, Haoyu Wang, Tivadar Török, Juliano Souza Ribeiro, Erik C. Cardoso, Yao Rong, Luyi Tian, Jackson A. Weir, Victor Chen, Luke W Koblan, Kathryn E Yost, Nicolas Mathey-Andrews, Edridge D’Souza, Andrew Russell, Robert R. Stickels, Karol Balderrama, Min Dai, Giovanni J. Marrero, Vipin Kumar, Anjali Saqi, Benjamin Herzberg, Benjamin Izar, Howard Chang, Joo-Hyeon Lee, Tyler Jacks, fei chen, Jonathan S. Weissman, Nir Yosef, Dian Yang, Jessie Xue, William M. Rideout III
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Nature
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Incorporating AI-optimized zinc finger proteins enhances the efficiencies and targeting ranges of miniature base editors
Abstract The therapeutic application of base editors is limited by their large sizes, which are beyond the packaging capabilities of adeno-associated viral (AAV) vectors. Despite recent progress that has identified many compact CRISPR proteins, the resulting miniature base editors often exhibit reduced activities and limited targeting scope.
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Introduction. Lower respiratory tract infections (LRTIs), particularly those acquired in hospitals, are an important cause of childhood morbidity and mortality. Understanding the aetiology and epidemiology of LRTIs is necessary for clinical management, reduction of antibiotic usage, vaccine development and prevention of nosocomial infection. Aim.
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Alfaria yunnanensis sp. nov., a novel myrothecium-like species isolated from Oryza sativa in Yunnan, China
Volume 76, Issue 4 Article metrics loading... /content/journal/ijsem/10.1099/ijsem.0.007130 Metrics References Crous PW, Shivas RG, Quaedvlieg W, van der Bank M, Zhang Y et al. Fungal Planet description sheets: 214-280. Persoonia 2014; 32:184–306 [View Article] [PubMed] [Google Scholar] Maharachchikumbura SSN, Hyde KD, Jones EBG, McKenzie EHC, Huang S-K et al. Towards a natural classification and backbone tree for Sordariomycetes.
Synthesis and Upcycling of All‐Carbon‐Backbone Degradable Polyethylene with Dispersed On‐Chain Ketones
Conflict of Interests The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available in the Supporting Information of this article. Supporting Information Filename Description anie70386-sup-0001-SuppMat.pdf4.2 MB Supporting Information References 1, , , , Chem. Rev. 2024, 124, 2327–2351, https://doi.org/10.1021/acs.chemrev.3c00587. 2, , , Prog. Polym. Sci. 2023, 143, 101713, https://doi.org/10.1016/j.progpolymsci.2023.101713.
Correction to “Two-Step Hydrothermal Preparation of Carbon Dots for Calcium Ion Detection”
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Negative‐Valent Platinum Stabilized by Pt─Ni Electron Bridges on Oxygen‐Deficient NiFe‐LDH for Enhanced Electrocatalytic Hydrogen Evolution
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202500595-sup-0001-SuppMat.docx20.3 MB Supporting Information References 1a) , , , , , , , , , , , , , , , , , , , Sci. Adv. 2024, 10, eadl3693; b) , , , , , , , , , Angew. Chem., Int. Ed. 2024, 63, 202315340; c) , , , , , , , , Adv. Funct. Mater. 2024, 34, 2405897. 2a) , , , , , , , , , , Nat. Commun. 2024, 15, 1342; b) , , , , Small 2024, 20, 2402846; c) , , , , , , , , Angew. Chem., Int.
The Mechanisms of Cadmium Stress Mitigation by Fungal Endophytes from Maize Grains
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Aldehyde End‐Capped Degradable Polyethylenes from Hydrogen‐Controlled Ethylene/CO Copolymerization
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Aldehyde End‐Capped Degradable Polyethylenes From Hydrogen‐Controlled Ethylene/CO Copolymerization
Conflict of Interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
CoPS/Co4S3 Heterojunction with Highly Exposed Active Sites and Dual‐site Synergy for Effective Hydrogen Evolution Reactions
Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
Quantification and statistical analysis Single-cell lineage tracing preprocessing pipeline and quality control filtering Each cell was sequenced in four sequencing libraries: a MULTI-seq library (for identifying sample identity), a target site library (for reconstructing phylogenies), an RNA-seq library (for measuring transcriptional states), and a Lenti-Cre-BC library (for verifying clonal identity).
Superior Reducing Carbon Dots from Proanthocyanidin for Free-Radical Scavenging and for Cell Imaging
Superior Reducing Carbon Dots from Proanthocyanidin for Free-Radical Scavenging and for Cell Imaging Excessive ROS will cause many harms to the human body and even cause diseases. Therefore, it is meaningful to detect and remove ROS, but there is no ideal material at present. In this paper, using procyanidins，a kind of plant extract with strong reducibility，as raw materials, the fluorescent carbon dots were prepared by hydrothermal method.
Bilayer hydrogel mixed composites that respond to multiple stimuli for environmental sensing and underwater actuation
Y. Cheng, C. Huang, D. Yang, K. Ren and J. Wei, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02242A If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center. Go to our Instructions for using Copyright Clearance Center page for details.
Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin
AbstractThe extent to which early events shape tumor evolution is largely uncharacterized, even though a better understanding of these early events may help identify key vulnerabilities in advanced tumors. Here, using genetically defined mouse models of small cell lung cancer (SCLC), we uncovered distinct metastatic programs attributable to the cell type of origin.
Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin
Research Articles Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin Dian Yang, Sarah K. Denny, Peyton G. Greenside, Andrea C. Chaikovsky, Jennifer J. Brady, Youcef Ouadah, Jeffrey M. Granja, Nadine S. Jahchan, Jing Shan Lim, Shirley Kwok, Christina S. Kong, Anna S. Berghoff, Anna Schmitt, H. Christian Reinhardt, Kwon-Sik Park, Matthias Preusser, Anshul Kundaje, William J. Greenleaf, Julien Sage and Monte M. Winslow
Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility
Identification of Two Distinct Chromatin Accessibility Landscapes within SCLC Differentially Accessible Regions Are in Gene Deserts, Evolutionarily Conserved, and Shared by Other Cell Types The Hyper-Accessible Samples Are Characterized by Nfib Copy Number Amplification Nfib Is Highly Expressed in Invasive Primary Tumors and Metastases, and Nfibhigh Cells Specifically Have the Ability to Disseminate NFIB Is Highly Expressed in a Subset of Human SCLC Primary Tumors and Metastases Genomic...
A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors
Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with high mortality. We used a systematic drug repositioning bioinformatics approach querying a large compendium of gene expression profiles to identify candidate U.S. Food and Drug Administration (FDA)–approved drugs to treat SCLC.
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