Barbara M. Grüner

1 Introduction Potamodromous species depend on a variety of habitats throughout their life cycle. For example, they spawn on gravel bars in swift currents, nurse in shallow littoral zones, and grow in deeper, faster areas. These distinct habitats must be accessible when needed. Thus, connectivity between these habitats is a prerequisite for sustaining fish populations.

Abstract Proteolysis-targeting chimeras (PROTACs) co-op the ubiquitin system for targeted protein degradation, creating opportunities to interrogate cellular functions of proteins through “chemical knockdown”. However, matched pairs of protein degraders and inhibitors, that possess high specificity and chemical complementarity, for individual components of the ubiquitin system have remained scarce. This includes reagents to modulate activity and abundance of deubiquitinases (DUBs).

Keywords PDAC MEK trametinib PLK1 volasertib synergism G2/M checkpoint cell cycle JNK KRAS G1 arrest cJUN MAPK therapy resistance PDO organoids Research topic(s) CP: Cancer Introduction Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal malignancies and ranks as the fourth leading cause of cancer-related deaths worldwide.1 Despite significant strides in comprehending the disease’s pathobiology and the introduction of precision oncology approaches, patient mortality rates...