Barbara M. Grüner

Abstract Proteolysis-targeting chimeras (PROTACs) co-op the ubiquitin system for targeted protein degradation, creating opportunities to interrogate cellular functions of proteins through “chemical knockdown”. However, matched pairs of protein degraders and inhibitors, that possess high specificity and chemical complementarity, for individual components of the ubiquitin system have remained scarce. This includes reagents to modulate activity and abundance of deubiquitinases (DUBs).

Keywords PDAC MEK trametinib PLK1 volasertib synergism G2/M checkpoint cell cycle JNK KRAS G1 arrest cJUN MAPK therapy resistance PDO organoids Research topic(s) CP: Cancer Introduction Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal malignancies and ranks as the fourth leading cause of cancer-related deaths worldwide.1 Despite significant strides in comprehending the disease’s pathobiology and the introduction of precision oncology approaches, patient mortality rates...

NEWS AND VIEWS 19 August 2020 A cellular condition called oxidative stress can kill cancer cells. The finding that skin cancer cells evade such destruction using lipids acquired while passing through lymphatic vessels reveals a mechanism that boosts cancer spread. Barbara M. Grüner & Barbara M.