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Diem Nguyen

As seen in: Nature, Wiley Online Library, MDPI, Archives of Public Health, Microbiology Research
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Articles

Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals

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By Gabriel Baldanzi, Anna Larsson, Sergi Sayols-Baixeras, Koen F. Dekkers, Ulf Hammar, Diem Nguyen, Tiscar Graells, Shafqat Ahmad, Camila Gazolla Volpiano, Guillaume Meric, Josef D. Järhult, Thomas Tängdén, Jonas Ludvigsson, Lars Lind, Johan Sundström, Karl Michaëlsson, Johan Ärnlöv, Beatrice Kennedy, Marju Orho-Melander, Tove Fall
| Nature Verified
Abstract Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome.
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Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation - Nature Genetics

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By Koen F. Dekkers, Kamalita Pertiwi, Gabriel Baldanzi, Per O Lundmark, Ulf Hammar, Marta Riise Moksnes, Eivind Coward, Maria Nethander, Ghassan Ali Salih, Mariam Miari, Diem Nguyen, Sergi Sayols-Baixeras, Aron C. Eklund, Jacob Bak Holm, H. Bjørn Nielsen, Camila Gazolla Volpiano, Guillaume Meric, Manonanthini Thangam, Liisa H. Hakaste, Tiinamaija Tuomi, Emma Ahlqvist, Christopher Smith, Marie Allen, Frank Reimann, Fiona M. Gribble, Claes Ohlsson, Kristian Hveem, Olle Melander, Peter M Nilsson, Gunnar Engström, J. Gustav Smith, Karl Michaëlsson, Johan Ärnlöv, Marju Orho-Melander, Tove Fall
| Nature Verified
Abstract Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1–OR51E2 locus, encoding sensors for microbiome-derived fatty acids, associated with microbial richness.
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Dominance of high-risk clones ST2 and ST571 and the diversity of resistance islands in clinical Acinetobacter baumannii isolates from Hanoi, Vietnam

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By Diem Nguyen, Minh Ngoc Nghiem, Dung Phuong Bui, Hop Thi Tran
| Microbiology Research
Article metrics loading... /content/journal/mgen/10.1099/mgen.0.001500 Download as PowerPoint /deliver/fulltext/mgen/11/9/mgen001500.html?itemId=/content/journal/mgen/10.1099/mgen.0.001500&mimeType=html&fmt=ahah References Ayoub Moubareck C, Hammoudi Halat D. Insights into Acinetobacter baumannii: a review of microbiological, virulence, and resistance traits in a threatening nosocomial pathogen. Antibiotics 2020; 9:119 [View Article] [Google Scholar] Castanheira M, Mendes RE, Gales AC.
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