Jacob Bak Holm

Abstract Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1–OR51E2 locus, encoding sensors for microbiome-derived fatty acids, associated with microbial richness.

Correction to: Nature Communications https://doi.org/10.1038/s41467-022-33050-0, published online 23 September 2022 The original version of this Article contained errors related to reporting of the estimation of the variance explained as follows: 1.

Study sample SCAPIS is a prospective population-based study of 30,154 men and women, aged 50–65 years, living in six municipality regions in Sweden. It was designed with the main aim to improve risk prediction and understanding of cardiovascular disease, chronic pulmonary obstructive disease, and related metabolic disorders14. After a pilot study in 2012, recruitment was initiated in 2014 and completed in 2018.