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Guillaume Meric on Muck Rack

Guillaume Meric

As seen in: Nature, PNAS, Cell Metabolism, The Lancet, medRxiv, The Journal of Allergy & Clinical Immunology
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Articles

Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals

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By Gabriel Baldanzi, Anna Larsson, Sergi Sayols-Baixeras, Koen F. Dekkers, Ulf Hammar, Diem Nguyen, Tiscar Graells, Shafqat Ahmad, Camila Gazolla Volpiano, Guillaume Meric, Josef D. Järhult, Thomas Tängdén, Jonas Ludvigsson, Lars Lind, Johan Sundström, Karl Michaëlsson, Johan Ärnlöv, Beatrice Kennedy, Marju Orho-Melander, Tove Fall
| Nature Verified
Abstract Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome.
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Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation - Nature Genetics

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By Koen F. Dekkers, Kamalita Pertiwi, Gabriel Baldanzi, Per O Lundmark, Ulf Hammar, Marta Riise Moksnes, Eivind Coward, Maria Nethander, Ghassan Ali Salih, Mariam Miari, Diem Nguyen, Sergi Sayols-Baixeras, Aron C. Eklund, Jacob Bak Holm, H. Bjørn Nielsen, Camila Gazolla Volpiano, Guillaume Meric, Manonanthini Thangam, Liisa H. Hakaste, Tiinamaija Tuomi, Emma Ahlqvist, Christopher Smith, Marie Allen, Frank Reimann, Fiona M. Gribble, Claes Ohlsson, Kristian Hveem, Olle Melander, Peter M Nilsson, Gunnar Engström, J. Gustav Smith, Karl Michaëlsson, Johan Ärnlöv, Marju Orho-Melander, Tove Fall
| Nature Verified
Abstract Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1–OR51E2 locus, encoding sensors for microbiome-derived fatty acids, associated with microbial richness.
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Deep learning for polygenic prediction: The role of heritability, interaction type and sample size

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By Gad Abraham, Guillaume Meric, Rodrigo Cánovas, Jason Grealey
| medRxiv
M.I. is a trustee of the Public Health Genomics (PHG) Foundation, a member of the Scientific Advisory Board of Open Targets, and has research collaborations with AstraZeneca, Nightingale Health and Pfizer which are unrelated to this study. This study was supported by the Victorian Government's Operational Infrastructure Support (OIS) program.
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