Inken Waltl on Muck Rack

Inken Waltl

As seen in: Nature, Cell Press, Journal of Infection
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Articles

A transcriptomic microglia taxonomy across mouse and human pathologies

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By Chintan Chhatbar, Roman Sankowski, Michael Schulz, Takashi Shimizu, Marius Schwabenland, Ori Staszewski, Christian Scheiwe, Katharina Borst, Anaelle Aurelie Dumas, Wesley Brandao, Omar Mossad, Adrià Dalmau Gasull, Maximilian Frosch, Daniel Erny, Martin Diebold, Janaki Manoja Vinnakota, Koliane Ouk, Inken Waltl, Michael LaMorte, Timothy R. Hammond, Giovanni Di Liberto, Ilena Vincenti, Mario Kreutzfeldt, Ibrahim T Mughrabi, Yousef Al-Abed, Thomas Blank, Melanie Meyer-Luehmann, Yanick J. Crow, Dimitry Ofengeim, Robert Zeiser, Jutta Gärtner, Andreas Meisel, Martin Schwemmle, Ulrich Kalinke, Jürgen Beck, Bertram R Bengsch, Robert Thimme, Oleg Butovsky, Tamara Seredenina, Richard M. Ransohoff, Francisco J. Quintana, Katrin Kierdorf, Doron Merkler, Christine Stadelmann, Josef Priller, Marco Prinz, Stefan Nessler, Ella Trost, Daniel Berchtold, Elena Guffart, Katharina Ternka, Mihaela Guranda, Marina Friesen, Nellwyn Hagen, Matthias Kettwig
| Nature Verified
Abstract Single-cell studies have revealed substantial microglial diversity in development, homeostasis and disease. However, a framework enabling comparison and stratification of microglial states across contexts is needed. Here we generated an atlas of myeloid cell states by single-cell RNA sequencing more than one million central nervous system cells from more than 30 physiological and pathological conditions.
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Beneficial and detrimental functions of microglia during viral encephalitis

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By Ulrich Kalinke, Inken Waltl
| Cell Press Verified
Highlights During homeostasis, microglia are the most abundant immune cell type within the central nervous system. Different microglia subsets in different brain areas maintain brain function and integrity. During virus-induced encephalitis, microglia are essential for antiviral defence and protection of the brain. Microglia activation and antiviral defence are regulated by crosstalk between neurons, astrocytes, and other cell types in the brain.
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