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Dingyin Tao on Muck Rack

Dingyin Tao

As seen in: Nature, Science Magazine, The Journal of Biological Chemistry
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Articles

A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis - Nature Communications

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By Xiaoying Liu, Bolormaa Baljinnyam, Alexey Zakharov, Tuan Xu, Tatiana K. Rostovtseva, Christopher A. LeClair, Josephine M. Egan, Hua Wang, Dingyin Tao, Mark Henderson, Antara Syam, Taylor Niehoff
| Nature Verified
Abstract Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control mechanism that also regulates lipid metabolism and calcium homeostasis. Dysregulation of ERAD and unfolded protein response underlies diseases including cancer, neurodegenerative disorders, and metabolic syndromes. Small molecule modulators of ERAD could enable mechanistic discovery and therapeutic intervention, but few have been identified.
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Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes - Nature Communications

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By Tuan Xu, Christopher A. LeClair, Brian M. Polster, Mark Henderson, Dingyin Tao
| Nature Verified
Cell culture HeLa cells (ATCC, CCL-2), HEK293 cells (ATCC, CRL-1573) and HCT116 cells (ATCC, CCL-247) were obtained from ATCC and cultured in complete Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10% fetal bovine serum as growth medium. HeLa cells stably expressing SP-S11-NHK-HA and S1-10 were established previously67. UBE2G2 KO 293 T cells were established in Dr. Yihong Ye’s laboratory (NIDDK/NIH, USA). JM109 and BL21(DE3) were obtained from New England Biolabs.
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Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens

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By Victor Clausse, Dingyin Tao, Subrata Debnath, Yuhong Fang
| The Journal of Biological Chemistry Verified
Victor Clausse‡, Dingyin Tao§1, Subrata Debnath¶1, Yuhong Fang§, Harichandra D. Tagad¶, Yuhong Wang§, Hongmao Sun§, Christopher A. LeClair§, Sharlyn J. Mazur¶, Kelly Lane‖, Zhen-Dan Shi‖, Olga Vasalatiy‖, Rebecca Eells**, Lynn K. Baker**, Mark J. Henderson§, Martin R. Webb‡‡2, Min Shen§, Matthew D. Hall§3, Ettore Appella¶, Daniel H. Appella‡ and Nathan P.
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