Xiaoying Liu
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Nature,
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PLOS,
BMJ Open,
MDPI,
PNAS,
SAGE Publishing,
Taylor & Francis Online,
ACS Publications
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Miao Sour Soup Modulates Hepatic Gluconeogenesis Through PI3K/Akt/Foxo1 Signaling in High-Fat Diet–Induced Rats
1 Introduction Hepatic gluconeogenesis, a crucial physiological mechanism for maintaining systemic glucose homeostasis, is essential for providing energy during fasting, famine, and stress situations (Zhao et al. 2023). In physiological homeostasis, the liver synthesizes glucose from non-carbohydrate precursors, such as lactate, pyruvate, and glucogenic amino acids, via gluconeogenesis, thereby maintaining glucose homeostasis (Xu et al. 2022).
Converging dopamine pathways onto basolateral amygdala neurons encode exploration decisions
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Keywords social interaction exploration dopaminergic neurons firing pattern ventral tegmental area D1R D2R Get full text access Log in, subscribe or purchase for full access. References 1. Fendt, M. ∙ Parsons, M.H. ∙ Apfelbach, R. ... Context and trade-offs characterize real-world threat detection systems: A review and comprehensive framework to improve research practice and resolve the translational crisis Neurosci. Biobehav. Rev. 2020; 115:25-33 2. Apfelbach, R. ∙ Blanchard, C.D. ∙ Blanchard, R.J. ...
By Chaowen Zheng, Xiaoying Liu, Anqi Wei, Bing Liu, Qianyun Zhang, Junjie Jiang, Xiaofeng Gao, Hong Fan, Anran Zhao, Xueting Duan, Xu Cheng, Haiyao Liu, Niki Gooya, Fenghan Mao, Aomei An, Shuaijie Zhong, Jie Jian, Wenxin Shen, Xingyao Dong, Kaikai Yang, Bianbian Wang, Ziyang Li, Jingxiao Huo, Jingyu Yao, Weiwei Li, Yu Lu, Junxi Kang, Kai Huang, Nan Dong, Yang Chen, Qian Song, Zigang Huang, Rong Huang, Shuqin Zhan, Han Xu, Yong Jiang, Chunxiang Zhang, Dan Xu, Haowen Liu, Jinghong Ma, Yuqing Zhang, Huadong Xu, Xinjiang Kang, Changhe Wang, Zhenli Xie
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Cell Press
Verified
A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis - Nature Communications
Abstract Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control mechanism that also regulates lipid metabolism and calcium homeostasis. Dysregulation of ERAD and unfolded protein response underlies diseases including cancer, neurodegenerative disorders, and metabolic syndromes. Small molecule modulators of ERAD could enable mechanistic discovery and therapeutic intervention, but few have been identified.
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