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Dominic Didiano

As seen in: Cell Press, Lab Manager
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Articles

The miR-216a-Dot1l Regulatory Axis Is Necessary and Sufficient for Müller Glia Reprogramming during Retina Regeneration

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By Matthew Kent Verified, Dominic Didiano, Nergis Kara, Kamya Rajaram
| Cell Reports Verified
Highlights • miR-216a is suppressed in Müller glia during retina regeneration • miR-216a suppression stimulates Müller glia reprogramming and proliferation • Dot1l is a target of miR-216a and required for Müller glia proliferation • miR-216a and Dot1l regulate Müller glia reprogramming through canonical Wnt signaling Summary Unlike the adult mammalian retina, Müller glia (MG) in the adult zebrafish retina are able to dedifferentiate into a “stem cell”-like state and give rise to multipotent...
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Fish Eyes May Hold Key to Regenerating Human Retinas

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By James Patton, Dominic Didiano
| Lab Manager Verified
Vanderbilt biologists James Patton, left, Mahesh Rao, and Dominic Didiano in the zebrafish facility. Photo credit: The Patton Lab/VanderbiltIf you were a fish and your retina was damaged, it could repair itself and your vision would be restored in a few weeks. Sadly, human eyes don’t have this beneficial ability. However, new research into retinal regeneration in zebrafish has identified a signal that appears to trigger the self-repair process.
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Fish eyes may hold key to regenerating human retinas

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By David Salisbury, James Patton, Dominic Didiano
| news.vanderbilt.edu
If you were a fish and your retina was damaged, it could repair itself and your vision would be restored in a few weeks. Sadly, human eyes don’t have this beneficial ability. However, new research into retinal regeneration in zebrafish has identified a signal that appears to trigger the self-repair process.
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