Dongdong Fan

Abstract Click to copy section linkSection link copied! Accurate prediction for the state-of-health (SOH) of lithium-ion batteries represents one of the core technologies for battery management in electric vehicle (EV) applications. As is known, battery performance degradation exhibits significant nonlinearity and stage-dependent characteristics.

Abstract Indirect hepatotoxicity remains a major challenge in drug development because of limited evaluation tools and mechanistic insight. Here, we construct three-dimensional multi-lineage hepatic organoids comprising five liver cell types derived from human embryonic stem cells, and in a screen of 58 hepatotoxic drugs, identify imipramine as an inducer of indirect hepatotoxicity.