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Articles by Drew Friedmann
Architecture of the serotonergic projectome in the mouse brain
Keywords serotonin projectome raphe neuromodulation axon mapping whole-brain imaging spatial transcriptomics animal behavior analysis Get full text access Log in, subscribe or purchase for full access. References 1. Glanzman, D.L. ∙ Mackey, S.L. ∙ Hawkins, R.D. ... Depletion of serotonin in the nervous system of Aplysia reduces the behavioral enhancement of gill withdrawal as well as the heterosynaptic facilitation produced by tail shock J. Neurosci. 1989; 9:4200-4213 2. Flavell, S.W. ∙ Pokala, N.
Generation of a DAT-P2A-Flpo mouse line for intersectional genetic targeting of dopamine neuron subpopulations
Highlights • DAT-P2A-Flpo mice allow genetic access to dopamine (DA) neurons • DAT+/Neurod6+ cells labeled with Flp/Cre reporters project to the NAc medial shell • Whole-brain imaging of DAT+/Neurod6+ cells reveals selective projection patterns • Optogenetic activation of DAT+/Neurod6+ cells evokes DA release in the medial shell Summary Dopaminergic projections exert widespread influence over multiple brain regions and modulate various behaviors including movement, reward learning, and...
Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set
Cerebellar evolution Cerebellar nuclei, substructures of the cerebellum, transfer information from the cerebellum to other parts of the brain. Using single-cell transcriptomics, Kebschull et al. have now identified a conserved pattern of cerebellar nuclei structure that has been repeated through evolution (see the Perspective by Hatten). Ranging from mice to chickens to humans, cerebellar nuclei are made up of region-specific excitatory neurons and region-invariant inhibitory neurons.
Mapping mesoscale axonal projections in the mouse brain using a 3D convolutional network
Teams are pursuing a dizzying array of therapeutic strategies to stymie COVID-19. It’s not yet clear which will work best.
Mapping Mesoscale Axonal Projections in the Mouse Brain Using A 3D Convolutional Network
New Results Drew Friedmann, Albert Pun, Eliza L Adams, Jan H Lui, Justus M Kebschull, Sophie M Grutzner, Caitlin Castagnola, Marc Tessier-Lavigne, Liqun Luo doi: https://doi.org/10.1101/812644 Abstract The projection targets of a neuronal population are a key feature of its anatomical characterization. Historically, tissue sectioning, confocal microscopy, and manual scoring of specific regions of interest have been used to generate coarse summaries of mesoscale projectomes.
Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems
The dorsal raphe (DR) constitutes a major serotonergic input to the forebrain and modulates diverse functions and brain states, including mood, anxiety, and sensory and motor functions. Most functional studies to date have treated DR serotonin neurons as a single population. Using viral-genetic methods, we found that subcortical- and cortical-projecting serotonin neurons have distinct cell-body distributions within the DR and differentially co-express a vesicular glutamate transporter.
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