Dured Dardari

The pathophysiology of Charcot neuroarthropathy (CN) includes a number of gray areas, particularly regarding the onset of inflammation which induces the disruption of the bone remodeling factor responsible for the onset of bone lysis.

Open AccessStudy Protocol by Dured Dardari 1,2,*, Louis Potier 3,4, Ariane Sultan 5,6, Maude Francois 7, Jocelyne M’Bemba 8, Benjamin Bouillet 9,10, Lucy Chaillous 11, Laurence Kessler 12, Aurelie Carlier 3, Abdulkader Jalek 5, Ayoub Sbaa 12, Laurent Orlando 13, Elise Bobony 13, Bruno Detournay 14, Hilmar Kjartansson 15, Ragna Bjorg Arsaelsdottir 15, Baldur Tumi Baldursson 15 and Guillaume Charpentier 13 1 Diabetic Foot Unit, Centre Hospitalier sud Francilien Corbeil Essonnes, 91100...

1. Introduction Pregnancy is characterized by elevated serum thyroxine-binding globulin concentrations, as well as increased renal blood flow and glomerular filtration, leading to increased iodide clearance from plasma, and thus loss of iodine. Increased type 3 deiodinase activity in the placenta increases the degradation of thyroxine to the inactive reverse triiodothyronine [1].