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Articles by Dylan Windell
The embryonic origins of site-specific arthritis
Abstract The cellular basis for site-specific inflammation remains unclear. In human fingers, proximal interphalangeal (PIP) joints are preferentially affected by inflammatory arthritis, whereas distal interphalangeal joints are spared, providing a model to investigate the predilection of inflammation to distinct sites.
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615 PREDICTING HISTOLOGICAL ACTIVITY IN ULCERATIVE COLITIS USING AI-DRIVEN ENDOSCOPIC DISEASE SCORING
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Mo2211 GENERALIZABLE AI MODELS FOR ENDOSCOPIC SCORING OF ULCERATIVE COLITIS SEVERITY ACROSS MULTIPLE INDEPENDENT DATASETS
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171 AI INFLAMMATION AND ARCHITECTURAL MODEL DIFFERENTIATES ACTIVE AND REMISSION ULCERATIVE COLITIS STATES ACROSS HISTOLOGICAL SCORING SYSTEMS
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Tissue resident memory T cells populate the human uveal tract
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Abstract The current concept is that the eye is an immune privileged site endowed with innate immune regulatory networks to maintain organ function. We now have evidence that resident T cells occupy intraocular tissues. In immune-mediated inflammatory diseases, such as psoriasis and rheumatoid arthritis, tissue resident T cells trigger disease flares in the skin and joints.
By Andrew D. Foers, Ian Reekie, Lakshanie C. Wickramasinghe, Amy Ward, Thomas Buckley Verified, Moustafa Attar, Sam Pledger, Ananya Bhalla, Robert Hedley, Sarah Hill, Dylan Windell, Keith Barton, Imran Masood, Mark Coles, Jonathan P. Sherlock, Andrew Dick, Sarah E. Coupland, Stephen N. Sansom, David Copland, Christopher Buckley, Srilakshmi Sharma, Soledad Aguilar-Munoa
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Nature
Verified
AI portal tract detection and characterisation for a regional analysis of steatosis and inflammation in MASLD, MASH and AIH
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AI portal tract detection and characterisation for a regional analysis of steatosis and inflammation in MASLD, MASH, and AIH
DW, AM, CB, HTB, SL, KH, PA, RK, PW and CL are employees at Perspectum Ltd. KF, EF, TK and RG are consultants for Perspectum Ltd. All other co-authors have no conflicts of interest to declare relevant to this work. Manuscript includes use of data generated via collaboration with: Yokohama City University Hospital, CymaBay Therapeutics Inc (acquired by Gilead Sciences), University of Birmingham and Childrens Memorial Health Institute in Warsaw (IPCZD).
A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution - Nature Communications
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Abstract Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTKlowCD48+ macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative regulators of inflammation which co-exist in frozen shoulder capsule tissues.
By Hamez Gacaferi, Jessica E. Ackerman, Peter Johnson, Ian Reekie, Moustafa Attar, Dylan Windell, Mariola Kurowska-Stolarska, Stefano Alivernini, Kathrin U Jansen, Angela Lee, James Charlesworth, Kate Powell, Dominic Furniss, Jonathan Rees, Derek W. Gilroy, Mark Coles, Andrew Carr, Stephen N. Sansom, Christopher Buckley, Carl-Philip Hackstein
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Nature
Verified
Author Correction: 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain
Summary of the voxel GCaMP6s fluorescence intensity obtained per anatomical region for each of the model chemoconvulsant compounds applied.
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