Eduardo J Contijoch

Research Article View ORCID ProfileGraham J. Britton, View ORCID ProfileEduardo J. Contijoch, Matthew P. Spindler, Varun Aggarwala, Belgin Dogan, Gerold Bongers, Lani San Mateo, Andrew Baltus, Anuk Das, View ORCID ProfileDirk Gevers, View ORCID ProfileThomas J. Borody, Nadeem O. Kaakoush, Michael A. Kamm, Hazel Mitchell, View ORCID ProfileSudarshan Paramsothy, Jose C. Clemente, View ORCID ProfileJean-Frederic Colombel, View ORCID ProfileKenneth W. Simpson, View ORCID ProfileMarla C.

Highlights • Bacteroides ovatus strain variation drives either high or low fecal IgA • CD4 + T cells are critical in B. ovatus-mediated gut IgA production • Cocktails of IgA high B. ovatus strains convert mice from low- to high-IgA producers Summary Fecal IgA production depends on colonization by a gut microbiota. However, the bacterial strains that drive gut IgA production remain largely unknown.

Strain-level differences in gut microbiome composition determine fecal IgA levels and are modifiable by gut microbiota manipulation Chao Yang, Ilaria Mogno, Eduardo J. Contijoch, Joshua N. Borgerding, Varun Aggarwala, Zhihua Li, Emilie K. Grasset, Drew S. Helmus, Marla C. Dubinsky, Saurabh Mehandru, Andrea Cerutti, Jeremiah J. Faith bioRxiv 544015; doi: https://doi.org/10.1101/544015