Edwyn B.L. Lo on Muck Rack

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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

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By Sumaiyah K. Rehman, Jennifer Haynes, Evelyne Collignon, Kevin Brown, Yadong Wang, Allison Nixon, Jeffrey P. Bruce, Jeffrey Wintersinger, Arvind Singh Mer, Cherry S. Leung, Evelyne Lima-Fernandes, Nicholas Pedley, Fraser Soares, Edwyn B.L. Lo
| ScienceDirect Verified
Highlights • CRC cells possess an equipotent capacity to enter a drug-tolerant persister state • Tumors that recur following a DTP state maintain clonal complexity • DTP-state tumors are similar to diapause, an embryonic survival program • Similar to diapause, DTPs are dependent on autophagy for survival Summary Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents.
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