Nicholas Pedley

Highlights • CRC cells possess an equipotent capacity to enter a drug-tolerant persister state • Tumors that recur following a DTP state maintain clonal complexity • DTP-state tumors are similar to diapause, an embryonic survival program • Similar to diapause, DTPs are dependent on autophagy for survival Summary Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents.

The confusion about the proposed GP co-payment is causing concern within the medical research community. The Government is considering backing away from the proposed co-payment because it will not be passed by the Senate. The co-payment will partly fund the proposed $20 billion medical research fund.