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Articles by Eileen White
A health-system-scale, episode-resolved multimodal atlas of cancer cachexia
Abstract Cancer cachexia is a wasting syndrome with outsized impact on morbidity and mortality, yet its drivers and systemic consequences remain poorly defined. In this study, we repurposed longitudinal clinicogenomic data from 52,236 patients with cancer profiled by MSK-IMPACT (2010–2024) at Memorial Sloan Kettering Cancer Center to define episode-resolved trajectories of consensus-defined cachectic weight loss and linked these events to outcomes, serology and tumor genotypes.
Author Correction: Unravelling cysteine-deficiency-associated rapid weight loss - Nature
Correction to: Nature https://doi.org/10.1038/s41586-025-08996-y Published online 21 May 2025 In the version of the article initially published, there was a copy-paste error in Extended Data Fig. 2f,g. Specifically, the muscle H&E panel for Day 3 Het No Cys was identical to the Day 7 KO Ctrl diet, and the Day 3 KO Ctrl panel was identical to the Day 7 KO No Cys. These errors involved the incorrect panels for Day 3 Het No Cys and Day 3 KO Ctrl.
Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Abstract Neuroblastoma is a highly lethal childhood tumour derived from differentiation-arrested neural crest cells1,2. Like all cancers, its growth is fuelled by metabolites obtained from either circulation or local biosynthesis3,4. Neuroblastomas depend on local polyamine biosynthesis, and the inhibitor difluoromethylornithine has shown clinical activity5.
Addendum: Unravelling cysteine-deficiency-associated rapid weight loss - Nature
Addendum to: Nature https://doi.org/10.1038/s41586-025-08996-y Published online 21 May 2025 A study by Lee et al. (Lee, A.H. et al. Cysteine depletion triggers adipose tissue thermogenesis and weight loss. Nat. Metab. https://doi.org/10.1038/s42255-025-01297-8 (2025)) similarly reports a 30% weight loss upon cysteine restriction in a Cse knockout mouse model.
Unravelling cysteine-deficiency-associated rapid weight loss - Nature
Abstract Around 40% of the US population and 1 in 6 individuals worldwide have obesity, with the incidence surging globally1,2. Various dietary interventions, including carbohydrate, fat and, more recently, amino acid restriction, have been explored to combat this epidemic3,4,5,6. Here we investigated the impact of removing individual amino acids on the weight profiles of mice.
Women in Autophagy: an initiative to promote gender parity in science - Nature Cell Biology
Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. Initiatives such as the Women in Autophagy network promote the careers of these underrepresented groups with a range of free, year-round scientific, mentoring and networking activities for all scientists.
Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer - Nature Communications
Abstract Cancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat oxidative stress and support reductive biosynthesis. One major NADPH production route is the oxidative pentose phosphate pathway (committed step: glucose-6-phosphate dehydrogenase, G6PD). Alternatives exist and can compensate in some tumors.
Embracing cancer complexity: Hallmarks of systemic disease
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PerspectiveVolume 187, Issue 7p1589-1616 1The Francis Crick Institute, London, UK 2Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK 3INSERM U981, Gustave Roussy, Villejuif, France 4AstraZeneca, Cambridge, UK 5Department of Medical Oncology, Gustave Roussy, Villejuif, France 6Paris Saclay University, Kremlin-Bicetre, France 7Laboratory of Integrative Systems Physiology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland...
By Charles Swanton, Elsa Bernard, Chris Abbosh, Fabrice André, Johan Auwerx, Allan Balmain, Dafna Bar-Sagi, René Bernards, Susan Bullman, James DeGregori, Catherine Elliott, Ayelet Erez, Gerard Evan, Mark A. Febbraio, Andres Hidalgo, Mariam Jamal-Hanjani, Johanna A. Joyce, Matthew G. Kaiser, Katja A. Lamia, Jason W. Locasale, Sherene Loi, Ilaria Malanchi, Miriam Merad, Kathryn Musgrave, Ketan Patel, Sergio A Quezada, Jennifer Wargo, Ashani T Weeraratna, Eileen White, Frank Winkler, John Wood, Karen Vousden, Douglas Hanahan
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Cell Press
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Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice - Nature Communications
Abstract Cancer cachexia is a systemic metabolic syndrome characterized by involuntary weight loss, and muscle and adipose tissue wasting. Mechanisms underlying cachexia remain poorly understood. Leukemia inhibitory factor (LIF), a multi-functional cytokine, has been suggested as a cachexia-inducing factor. In a transgenic mouse model with conditional LIF expression, systemic elevation of LIF induces cachexia.
Autophagy Regulates Stress Responses, Metabolism, and Anticancer Immunity
Highlights Cancers upregulate autophagy to sustain metabolism and survival in a tumor cell-autonomous fashion. Autophagy sustains the essential tumor nutrients arginine and alanine. Autophagy mitigates stress and is functionally interdependent on the p53, NRF2, and LKB1 stress-response pathways. Host autophagy promotes tumor growth by providing essential tumor nutrients in a tumor cell-nonautonomous fashion. Autophagy promotes immune tolerance by suppressing T cell activation.
Abstract IA19: Role of autophagy in cancer metabolism
Oral Presentations - Invited Abstracts Eileen P. White DOI: 10.1158/1538-7445.CAMODELS2020-IA19 Published June 2020 Abstracts: AACR Special Conference on the Evolving Landscape of Cancer Modeling; March 2-5; San Diego, CA Abstract Autophagy captures intracellular components and delivers them to lysosomes, where they are degraded and recycled to sustain metabolism and enable survival in starvation.
Autophagy and Tumor Metabolism
Given the diverse substrates that can be degraded via autophagy, it is not surprising that autophagy has the potential to fuel nearly all aspects of central carbon metabolism (Guo and White, 2017xAutophagy, metabolism, and cancer. Guo, J.Y. and White, E. Cold Spring Harb. Symp. Quant. Biol. ; Crossref | PubMedSee all References, Rabinowitz and White, 2010xAutophagy and metabolism. Rabinowitz, J.D. and White, E. Science.
Mitochondria and Cancer
Decades ago, Otto Warburg observed that cancers ferment glucose in the presence of oxygen, suggesting that defects in mitochondrial respiration may be the underlying cause of cancer. We now know that the genetic events that drive aberrant cancer cell proliferation also alter biochemical metabolism, including promoting aerobic glycolysis, but do not typically impair mitochondrial function.
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