Ekrem Emrah Er

Keywords MRTFA SRF KCNMA1 KCNMB1 cancer metastasis cell stiffness ion channels mechanobiology mechanosurveillance Introduction Cellular stiffness is a dynamically regulated property that allows cells to deform with external force and respond to biochemical and mechanochemical stimuli in the microenvironment.1 Maintenance and regulation of cellular stiffness and mechanoadaptation play key roles in various physiological and pathological states.

In the version of this Article originally published, the authors inadvertently included the term ‘pericytic mimicry’ in relation to ref. 54. This has now been corrected by inserting an additional reference at position 51 and amending the text in the Discussion relating to ‘pericytic mimicry’, ref. 54 and pericyte-like spreading. The original refs 51–70 have also been renumbered. Furthermore, Fig.

(a) Confocal images of GFP+ MDA231-BrM (green) cells spreading along the mouse brain vasculature (lectin staining, red) after infiltrating the brain parenchyma of a mouse via the arterial circulation 7 d after injection (scale bar, 20μm). (b) GFP+ MDA231-LM cells (green) generating vascular coopting protrusions (arrowheads) over alveolar blood capillaries (lectin staining, red) after extravasation from the venous circulation into the lungs of a mouse, 2 d after tail vein injection.