Elesa McDonald

Keywords integrated stress response ribosome translation ribosome collisions Gcn2 Gcn4 Mbf1 Introduction During their lifetime, organisms face a multitude of stresses that can be detrimental for cellular homeostasis and that have driven the evolution of distinct stress-response pathways that allow organisms to survive and adapt through regulation of gene expression.

Abstract Endogenous and exogenous chemical agents are known to compromise the integrity of RNA and cause ribosome stalling and collisions. Recent studies have shown that collided ribosomes serve as sensors for multiple processes, including ribosome quality control (RQC) and the integrated stress response (ISR). Since RQC and the ISR have distinct downstream consequences, it is of great importance that organisms activate the appropriate process.