Elif Arik Sever

Keywords pancreatic cancer synapse glutamatergic receptor NMDAR L-glutamate GRIN2D neural invasion innervation Introduction Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy, ranking among the primary contributors to tumor-associated mortality worldwide.1,2,3,4,5,6,7 Human PDAC demonstrates an exceptionally high incidence of neural invasion (NI) and neuroplastic alterations.8,9,10,11 Cancer cells infiltrating nerves exploit them as conduits for dissemination, resulting in...

Abstract We investigated the association between pancreatic ductal adenocarcinoma (PDAC) subtypes and neural invasion (NI) status in order to assess what factors influence the inter-tumor heterogeneity of NI. We built single-sample classifiers for prominent subtype schemes using multiple approaches. We predicted the subtype labels of samples with known NI status using the classifiers based on pairwise gene expression comparisons, which were consistently the best-performing models.