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Elisar Barbar on Muck Rack

Elisar Barbar

As seen in: Wiley Online Library, PLOS, MDPI, BioRxiv, Cell Press, The Journal of Biological Chemistry
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Articles

Multifaceted multivalency with a hub protein

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By Douglas Walker, Elisar Barbar
| Wiley Online Library Verified
Conflict of interest The authors declare no conflict of interest. References 1, & (2024) Multivalency emerges as a common feature of intrinsically disordered protein interactions. Curr Opin Struct Biol 84, 102742. doi: 10.1016/j.sbi.2023.102742 2, , & (2014) The mechanism of dynein light chain LC8-mediated oligomerization of the Ana2 centriole duplication factor. J Biol Chem 289, 20727–20739.
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Improving parameter inference by resolving Bayesian prior ambiguity via multi-dataset analysis: Application to isothermal titration calorimetry

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By Lisa C Otten, Douglas Walker, Elisar Barbar, Daniel Zuckerman
| BioRxiv
Abstract Isothermal titration calorimetry (ITC) is a powerful technique for probing biomolecular interactions. However, accurate determination of binding parameters—such as enthalpy and free energy—as well as associated uncertainties can be hindered by noise and concentration variability.
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Quantifying cooperative multisite binding in the hub protein LC8 through Bayesian inference

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By Aidan Estelle, Elisar Barbar, Daniel Zuckerman, August George
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Abstract Multistep protein-protein interactions underlie most biological processes, but their characterization through methods such as isothermal titration calorimetry (ITC) is largely confined to simple models that provide little information on the intermediate, individual steps.
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