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Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections

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By Marco Di Gioia, Valentina Poli, Piao Tan, Roberto Spreafico, Anne H.Y. Chu, Alex G. Cuenca Verified, Zhongyang Wu, Mehdi Benamar, Laura Pandolfi, Federica Meloni, Fatemeh Askarian, Jason Hsiao, Victor Nizet, Philip L.S.M. Gordts, Joseph L. Witztum, Talal Chatila, Janet Chou, Xu Zhou, James R. Springstead, Ivan Zanoni, Elizaveata Borroum
| Cell Press Verified
Keywords macrophages pattern recognition receptor PRR pathogen-associated molecular pattern PAMP damage-associated molecular pattern DAMP epigenetic sepsis ARDS Get full text access Log in, subscribe or purchase for full access. References 1. Medzhitov, R. The spectrum of inflammatory responses Science. 2021; 374:1070-1075 2. Medzhitov, R. ∙ Schneider, D.S. ∙ Soares, M.P. Disease tolerance as a defense strategy Science. 2012; 335:936-941 3. Meizlish, M.L. ∙ Franklin, R.A. ∙ Zhou, X. ...
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