Victor Nizet on Muck Rack

Victor Nizet

La Jolla
As seen in: Nature, Frontiers, Science Magazine, Cell Press, Stem Cell Reports, The San Diego Union-Tribune, medRxiv, Journal of Pharmacology and Experimental Therapeutics, The Journal of Biological Chemistry, The Journal of Immunology
Physician/Scientist, Bacterial Pathogenesis, Innate Immunity, Experimental ID Rx, Questionable Puns/Memes, Fighting AMR @CHARM_UCSD 🇧🇪🇬🇷🇺🇸🇸🇪
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Articles

Pneumococcal S protein coordinates cell wall modification and repair to resist host antimicrobials - Nature Microbiology

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By Jessica Burnier, Kevin Bruce, Ho-Ching Tiffany Tsui, Johann Mignolet, Victor Nizet
| Nature
Abstract S protein is conserved among streptococci and contributes to group A Streptococcus virulence, but the mechanisms involved are unclear. Here we used genetic, biochemical, single-molecule, in vitro and in vivo analyses to show that S protein is crucial for resistance against host-derived antimicrobials by coordinating cell wall modification and repair.
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Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections

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By Marco Di Gioia, Valentina Poli, Piao Tan, Roberto Spreafico, Anne H.Y. Chu, Alex G. Cuenca , Zhongyang Wu, Mehdi Benamar, Laura Pandolfi, Federica Meloni, Fatemeh Askarian, Jason Hsiao, Victor Nizet, Philip L.S.M. Gordts, Joseph L. Witztum, Talal Chatila, Janet Chou, Xu Zhou, James R. Springstead, Ivan Zanoni, Elizaveata Borroum
| Cell Press
Keywords macrophages pattern recognition receptor PRR pathogen-associated molecular pattern PAMP damage-associated molecular pattern DAMP epigenetic sepsis ARDS Get full text access Log in, subscribe or purchase for full access. References 1. Medzhitov, R. The spectrum of inflammatory responses Science. 2021; 374:1070-1075 2. Medzhitov, R. ∙ Schneider, D.S. ∙ Soares, M.P. Disease tolerance as a defense strategy Science. 2012; 335:936-941 3. Meizlish, M.L. ∙ Franklin, R.A. ∙ Zhou, X. ...
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Transient Vascular Occlusions in a Zebrafish Model of Tuberculous Meningitis

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By Megan Hayes, Sumedha Ravishankar, Victor Nizet, Cressida A. Madigan
| biorxiv.org
Abstract Tuberculous meningitis (TBM), caused by Mycobacterium tuberculosis, is a severe manifestation of tuberculosis that occurs when the bacteria invade the brain. In addition to extensive inflammation, vascular complications such as stroke frequently arise, significantly increasing the risk of disability and death. However, the mechanisms underlying these vascular complications remain poorly understood, as current knowledge is derived exclusively from human studies.
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