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Articles by Ellen Puré
Bispecific antibody engineered extracellular vesicles redirect T cells to prevent postoperative epidural fibrosis
Abstract Epidural fibrosis (EF) is a frequent and debilitating complication that impairs recovery following spinal surgery, yet effective targeted therapies are lacking. Here we observe enrichment of FAP⁺ fibroblasts at surgical sites in patients after laminectomy. To therapeutically target this subset, we develop bispecific antibody–decorated extracellular vesicles (BsAb EVs), which redirect endogenous T cells to eliminate FAP⁺ fibroblasts in situ.
Dupilumab attenuate IL-4 and IL-13 synergistic effect on airway remodeling in asthma via blocking IL-4Rα/STAT6 axis
Abstract Airway fibrosis in severe asthma is a hallmark of disease pathology, yet the mechanisms driving fibroblast activation remain incompletely understood. While interleukin-4 (IL-4) and interleukin-13 (IL-13) are central to type 2 inflammation, their combined role in directly promoting human lung fibroblast-mediated fibrosis is not well defined.
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer - Nature Cell Biology
Abstract Durotaxis, cell migration along stiffness gradients, is linked to embryonic development, tissue repair and disease. Despite solid in vitro evidence, its role in vivo remains largely speculative. Here we demonstrate that durotaxis actively drives disease progression in vivo in mouse models of lung fibrosis and metastatic pancreatic cancer. In lung fibrosis, durotaxis directs fibroblast recruitment to sites of injury, where they undergo mechano-activation into scar-forming myofibroblasts.
The fibroinflammatory response in cancer - Nature Reviews Cancer
Abstract Fibroinflammation refers to the highly integrated fibrogenic and inflammatory responses mediated by the concerted function of fibroblasts and innate immune cells in response to tissue perturbation. This process underlies the desmoplastic remodelling of the tumour microenvironment and thus plays an important role in tumour initiation, growth and metastasis.
Mesenchymal Cell Plasticity and Perfidy in Epithelial Malignancy
Stromal complicity in epithelial carcinogenesis contributes to immune suppression and treatment resistance, but not all cancer-associated fibroblasts (CAFs) are bad actors. Identifying and targeting protumorigenic CAFs while preserving their antitumorigenic counterparts is the challenge. The risk is the possibility of making things worse; the reward is the potential to transform the care of and prognosis for patients with solid tumors.
Stiffness-dependent motility and proliferation uncoupled by deletion of CD44
ECM-coated polyacrylamide hydrogels have been used extensively to study how cells sense and respond to the physical characteristics of their microenvironments because their tunable mechanical properties can mimic the physiological and pathological elasticity of tissues38,39. To investigate role of CD44 in stiffness-dependent motility, we generated FN-coated polyacrylamide hydrogels of elastic moduli ranging from 2–4 kPa (hereafter called “soft”) to 18–20 kPa (hereafter called “stiff”).
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