Ellen Yu

1 Introduction A company's environmental innovation activities can contribute to addressing environmental challenges and aligning with long-term sustainability objectives. Working towards the global net-zero target by 2050 (e.g., IPCC 2018), many companies are increasing investment in environmental innovation in response to stricter regulations worldwide (e.g., IMF 2023).

Abstract Background This study compared maternal and foetal outcomes of managing placenta accreta spectrum (PAS) disease with and without prophylactic internal iliac balloon occlusion (IIABO) at a tertiary hospital between 2002 and 2021. Methods This retrospective cohort study included patients with confirmed PAS disorder, comparing maternal and foetal outcomes between those who underwent IIABO before caesarean delivery and those who did not, both receiving standardised multidisciplinary care.

Highlights • Targeting MCL-1 induces DNA damage and impairs cell proliferation • MCL-1 regulates DNA integrity and cell-cycle progression independent from apoptosis • Replicative stress induces MCL-1 interaction with minichrosome maintenance complex • Noncanonical roles of MCL-1 expand the benefits and risks of therapeutic targeting Summary MCL-1 is a high-priority target due to its dominant role in the pathogenesis and chemoresistance of cancer, yet clinical trials of MCL-1 inhibitors are...