Emily Beebe

January 12, 2025 Categories: It was 2022 when I received the worst news in my life. Little did I know that 2022 and half of 2023 would follow suit. In December 2022, my father was diagnosed with Stage 3C colon cancer, which was one step away from metastatic cancer, which is cancer that spreads to other organs of the body.

Highlights • GIPR is expressed and functionally signals in both human and mouse adipocytes • Tirzepatide signals to adipocytes via long-acting GIPR agonism • Tirzepatide regulates adipocyte lipid and glucose storage as well as lipid efflux • Tirzepatide regulation of adipocyte function likely contributes to overall efficacy Summary Tirzepatide, a glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor (GIPR/GLP-1R) agonist, has, in clinical trials, demonstrated greater...