Keywords thermoreceptor trafficking guanylyl cyclase plasticity AFD C. elegans Results and discussion C. elegans exhibits a preference for its recently experienced temperature when placed on a thermal gradient.11,12 This behavioral plasticity is mediated via adaptation of the sensory response (T∗AFD) and synaptic output threshold of the AFD thermosensory neuron pair.10,13,14,15,16,17 Thus, moving C.