Erez N. Baruch
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Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit
Keywords colon cancer anti-tumor immunity mucus microbiome Mucispirillum schaedleri XCL1 cDC1 sulfur amino acids NKT Get full text access Log in, subscribe or purchase for full access. References 1. Siegel, R.L. ∙ Wagle, N.S. ∙ Cercek, A. ... Colorectal cancer statistics, 2023 CA Cancer J. Clin. 2023; 73:233-254 2. Topalian, S.L. ∙ Drake, C.G. ∙ Pardoll, D.M. Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy Cancer Cell. 2015; 27:450-461 3. Ciardiello, D.
Cultivating the microbiome to enhance cancer immunotherapy
Three recently published studies demonstrate the feasibility of modulating gut microorganisms using faecal microbiota transplantation (FMT) in patients receiving immune-checkpoint inhibitors (ICIs) in the first-line setting, expanding the evidence that FMT can augment response to ICIs. Herein, we discuss several opportunities for refining these efforts in order to increase the rigour and clinical benefit from microbiota modulation trials in oncology.
Cancer-Induced Nerve Injury Promotes Resistance to Anti-PD-1 Therapy
10.1038/s41586-025-09370-8 Post-print Animals, Programmed Cell Death 1 Receptor, Mice, Humans, Drug Resistance, Neoplasm, Female, Male, Interleukin-6, Melanoma, Interferon Type I, Tumor Microenvironment, Receptor, Interferon alpha-beta, Stomach Neoplasms, Skin Neoplasms, Peripheral Nerve Injuries, Carcinoma, Squamous Cell, Inflammation, Signal Transduction, Immune Checkpoint Inhibitors, Neurons, Neoplasms, Neoplasm Invasiveness, Tumour immunology, Cancer microenvironment, Immunotherapy,...
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