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Articles by Eric Betzig
A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms
Abstract Understanding biological systems requires observing features and processes across vast spatial and temporal scales, spanning nanometers to centimeters and milliseconds to days, often using multiple imaging modalities within complex native microenvironments.
Unstructured transcription factor interactions enable emergent specificity
Abstract How intrinsically disordered regions (IDRs) influence chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We employed proximity-assisted photoactivation (PAPA), a single-molecule protein-protein interaction sensor, to investigate how IDRs might influence TF interactions with each other and with chromatin in live cells. We found that the Sp1 DNA binding domain (DBD) interacted poorly with chromatin and did not colocalize with Sp1.
Oblique line scan illumination enables expansive, accurate and sensitive single-protein measurements in solution and in living cells - Nature Methods
Abstract An ideal tool for the study of cellular biology would enable the measure of molecular activity nondestructively within living cells. Single-molecule localization microscopy (SMLM) techniques, such as single-molecule tracking (SMT), enable in situ measurements in cells but have historically been limited by a necessary tradeoff between spatiotemporal resolution and throughput.
Image processing tools for petabyte-scale light sheet microscopy data - Nature Methods
Abstract Light sheet microscopy is a powerful technique for high-speed three-dimensional imaging of subcellular dynamics and large biological specimens. However, it often generates datasets ranging from hundreds of gigabytes to petabytes in size for a single experiment. Conventional computational tools process such images far slower than the time to acquire them and often fail outright due to memory limitations.
A Cell Observatory to reveal the subcellular foundations of life - Nature Methods
Imaging the 4D choreography of subcellular events in living multicellular organisms at high spatiotemporal resolution could reveal life’s fundamental principles. Yet extracting these principles from petabyte-scale image data requires fusing advanced light microscopy and cutting-edge machine learning models with biological insight and expertise.
Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina - Communications Biology
Zebrafish husbandry and transgenic lines All studies were carried out in accordance with recommendations by the Office of Laboratory Animal Welfare (OLAW) for zebrafish studies and an approved Johns Hopkins University Animal Care and Use Committee animal protocol. All fish were maintained using established conditions at 28.5 ◦C with a 14:10 h light:dark cycle. Previously published transgenic lines used here included: Tg(rho:YFP Eco.
Long-term volumetric imaging meets subcellular resolution: Lattice light-sheet microscopy comes of age
Webinar Technology This webinar is brought to you by the Science/AAAS Custom Publishing Office Since it was first described and demonstrated in 2014, lattice light-sheet microscopy has been exciting the research community. This technology combines the gentleness of conventional light-sheet imaging with the high resolution of confocal microscopes, allowing living samples to be imaged over longer periods of time and with subcellular resolution.
New Microscopy Technique Shows Cells’ 3-D Ultrastructure in New Detail
The method melds the best of super-resolution fluorescence and electron microscopy to show how proteins relate to cells’ fine structure. Inside a cell, tentacled vesicles shuttle cargo for sorting. Neighboring neurons cling to one another through a web-like interface. DNA rearranges in the nucleus as stem cells differentiate into neurons. And a new microscopy technique shows it all, in exquisite detail.
Imaging Intracellular Fluorescent Proteins at Nanometer Resolution
Report Eric Betzig1,2,*,†, George H. Patterson3, Rachid Sougrat3, O. Wolf Lindwasser3, Scott Olenych4, Juan S. Bonifacino3, Michael W. Davidson4, Jennifer Lippincott-Schwartz3, Harald F. Hess5,* 1 Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA. 2 New Millennium Research, LLC, Okemos, MI 48864, USA. 3 Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA.
Single Molecules, Cells, and Super‐Resolution Optics (Nobel Lecture)
Corresponding Author Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Dr., Ashburn, VA 20147 (USA) Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Dr., Ashburn, VA 20147 (USA)Search for more papers by this author
Single Molecules, Cells, and Super‐Resolution Optics (Nobel Lecture)
Corresponding Author Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Dr., Ashburn, VA 20147 (USA) Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Dr., Ashburn, VA 20147 (USA)Search for more papers by this author
Citation Results
Citation Results High-density three-dimensional localization microscopy across large volumes Wesley R Legant Lin Shao Jonathan B Grimm Timothy A Brown Daniel E Milkie Brian B Avants Luke D Lavis & Eric Betzig Nature Methods aop, (2016) | doi:10.1038/nmeth.3797.
Generating the best superresolution microscopy data: Finding the right tool for the right job
Superresolution microscopy has recently been making headlines again, not least because it was the breakthrough that spurred Eric Betzig, Stefan Hell, and William Moerner to be awarded the Nobel Prize for Chemistry in 2014. The number of superresolution technologies keeps increasing, along with an alphabet soup of acronyms that includes SIM, SPIM, STED, PALM, and STORM.
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