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Articles by Erman Chen
SCAP downregulation promotes intervertebral disc degeneration through 20-HETE mediated enhancement of macrophage pro-inflammatory responses
Abstract Intervertebral disc degeneration (IVDD) is increasingly recognized as an inflammation-driven disorder in which macrophage infiltration plays a pivotal role. Although metabolic pathways regulate macrophage immune responses, the immunometabolic mechanisms connecting macrophage activation and disc degeneration remain unclear. The sterol regulatory element–binding protein cleavage–activating protein (SCAP) was demonstrated as a key regulator of macrophage inflammatory responses.
Youthfulness of marrow Adipoq + cells maintained by Cbfβ facilitates stem cell-based bone repair
Abstract Exhaustion of skeletal stem and progenitor cells (SSPCs) drives age-related delays in fracture repair, yet the upstream regulators of SSPC maintenance are unclear. We identify that core-binding factor β (Cbfβ) in bone marrow Adipoq+ cells (BMACs) is essential for maintaining SSPC number and function. Cbfβ deletion in BMACs (CKO) leads to SSPC depletion, including periosteal populations, and impairs bicortical fracture healing in mice.
A circuit linking dentate gyrus and retrosplenial granular cortex regulates fracture healing in male mice
Abstract Traumatic brain injury often accelerates fracture repair, but the neural circuits linking brain state to bone healing remain unclear. Here we show that, in male mice, a hippocampal–cortical circuit linking the dentate gyrus (DG) and the retrosplenial granular cortex (RSGc) regulates repair after bone injury. Skeletal injury increased activity–associated labeling in both regions.
Osteoblast-derived osteomodulin restrains osteoclastogenesis via ITGB8/RRM2-mediated reduction of mitochondrial respiration and mitochondrial ATP production
Abstract Osteoporosis is driven in part by excessive osteoclast-mediated bone resorption, yet osteoblast-derived extracellular cues that restrain osteoclast bioenergetics remain incompletely defined. Here we identify osteomodulin (OMD), a matrix-associated osteoblast-derived protein that is reduced in the bone tissue and serum of postmenopausal patients with osteoporosis.
Arthroscopy-Assisted Reduction Percutaneous Internal Fixation Versus Open Reduction Internal Fixation for Tibial Plateau Fracture: A Systematic Review and Meta-analysis - Liangjun Jiang, Erman Chen, Lu Huang, Cong Wang, 2021
Tibial plateau fractures, which are typically caused by high-energy trauma or osteoporosis in older adults, comprise approximately 1% of all fractures,2,4,5 and many different surgical techniques and approaches have been described for the management of tibial plateau fractures.18,42 There are 2 principles in the treatment of tibial plateau fractures: one is the anatomic reduction of the articular surface and reconstruction of the mechanical axis of the lower limb, and the other is to...
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