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Ruiying Chen

As seen in: Nature, Wiley Online Library, arXiv, MDPI, Cell Press, The Journal of Clinical Investigation
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Articles

Youthfulness of marrow Adipoq + cells maintained by Cbfβ facilitates stem cell-based bone repair

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By Shali Wu, Wei Qian, Ruiying Chen, Erman Chen, Meizhu Wang, Cui Zhang, Chenhe Zhou, Luyang Yu, Mengjie Wu, Yi-Ping Li, Mengrui Wu, Tiannan Huang
| Nature Verified
Abstract Exhaustion of skeletal stem and progenitor cells (SSPCs) drives age-related delays in fracture repair, yet the upstream regulators of SSPC maintenance are unclear. We identify that core-binding factor β (Cbfβ) in bone marrow Adipoq+ cells (BMACs) is essential for maintaining SSPC number and function. Cbfβ deletion in BMACs (CKO) leads to SSPC depletion, including periosteal populations, and impairs bicortical fracture healing in mice.
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Computer Science > Computation and Language

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By Ruiying Chen, Haoyu Huang, Yuren Lai
| arXiv
Hierarchical Graph Retrieval-Augmented Generation (GraphRAG) organizes corpus knowledge at multiple levels of granularity, yet fixed context construction may fail to translate these multi-resolution representations into a context suited to the current query. We identify this mismatch as the representation--inference gap.
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Computer Science > Computation and Language

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By Ruiying Chen, James Cheng
| arXiv
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