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Ernest Iu

As seen in: Nature, BioRxiv, Cell Press
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Articles by Ernest Iu

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration

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By Ernest Iu, Alexander Bogatch, Wenjun Deng, Jonathan Humphries Verified, Changsong Yang, Fernando Valencia, Chengyin Li, Christopher Mcculloch, Guy Tanentzapf, Tatyana M. Svitkina, Martin Humphries, Sergey V. Plotnikov
| Cell Press Verified
Keywords cell migration actin cytoskeleton Ca2+ signaling RhoA lamellipodia TRPV4 CaMKII cell protrusion TEM4 Arhgef17 Get full text access Log in, subscribe or purchase for full access. References 1. SenGupta, S. ∙ Parent, C.A. ∙ Bear, J.E. The principles of directed cell migration Nat. Rev. Mol. Cell Biol. 2021; 22:529-547 2. Yamada, K.M. ∙ Sixt, M. Mechanisms of 3D cell migration Nat. Rev. Mol. Cell Biol. 2019; 20:738-752 3. Leithner, A. ∙ Eichner, A. ∙ Müller, J. ...
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A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration

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By Ernest Iu, Wenjun Deng, Jon Humphries, Alexander Bogatch
| BioRxiv
Abstract Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin–based lamellipodia protrusions, powered by actin polymerization, which is tightly regulated by signaling pathways, including Rho GTPases and Ca2+ signaling. While the importance of Ca2+ signaling in lamellipodia protrusions has been established, the molecular mechanisms linking Ca2+ to lamellipodia assembly are unknown.
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Membrane ruffling is a mechanosensor of extracellular fluid viscosity - Nature Physics

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By NIlay Taneja, Taekjip Ha, Jian Liu, Yun Chen, Ernest Iu, Myung Hyun Jo, Wei-Hung Jung
| Nature Verified
Abstract Cell behaviour is affected by the physical forces and mechanical properties of cells and their microenvironment. The viscosity of extracellular fluid—a component of the cellular microenvironment—can vary by orders of magnitude, but its effect on cell behaviour remains largely unexplored. Using biocompatible polymers to increase the viscosity of the culture medium, we characterize how viscosity affects cell behaviour.
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