Evandro R. Winkelmann

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Peli1–/– mice are more resistant to systemic WNV infection. Peli1 promotes microglia-mediated brain inflammation in the course of EAE induction (2). To investigate the role of Peli1 in WNV encephalitis, we infected WT and Peli1–/– mice i.p. with 100 focus-forming units (FFU) of the WNV 385-99 strain and monitored them daily for survival (Figure 1A). Peli1–/– mice (39% survival) were more resistant to WNV infection than were WT controls (9.5% survival).