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Evolutionary history of Jamestown Canyon virus reveals complex multi-vector ecology
Keywords Jamestown Canyon virus arbovirus phylogenetics sequencing virus evolution disease ecology mosquitoes Introduction Arthropod-borne viruses, or arboviruses, represent a diverse range of pathogens impacting the health of humans and animals.1,2,3 Many arbovirus species remain understudied due to their complex transmission cycles (e.g., a wide range of invertebrate vectors and vertebrate hosts) that present challenges to traditional epidemiological methods.4,5 Among these species, the...
Navigating sampling bias in discrete phylogeographic analysis: assessing the performance of an adjusted Bayes factor
Abstract Bayesian phylogeographic inference is widely used in molecular epidemiological studies to reconstruct the dispersal history of pathogens. Discrete phylogeographic analysis treats geographic locations as discrete traits and infers lineage transition events among them, and is typically followed by a Bayes factor (BF) test to assess the statistical support.
Comparative performance of novel viral landscape phylogeography approaches
Abstract The fast rate of evolution in RNA viruses implies that their evolutionary and ecological processes occur on the same time scale. Genome sequences of these pathogens can therefore contain information about the processes that govern their transmission and dispersal. In particular, landscape phylogeographic approaches use phylogeographic reconstructions to investigate the impact of environmental factors and variables on the spatial spread of viruses.
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