Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Department of Medicine, Weill Cornell Medical College, New York, NY, USA Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Highlights • STK11/KEAP1 co-mutation promotes cell proliferation, independent of KRAS status • NRF2 activity is enhanced in STK11/KEAP1 co-mutation beyond KEAP1 loss alone • STK11 and KEAP1 mutations each independently promote ferroptosis protection • SCD1 protects STK11/KEAP1 co-mutant LUAD from ferroptosis and is essential for survival Summary Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma (LUAD) are associated with aggressive tumor growth, resistance to...
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
