Fuying Ma

Abstract Mutations in the human SPTLC1 gene have recently been linked to early onset amyotrophic lateral sclerosis (ALS), characterized by global atrophy, motor impairments, and symptoms such as tongue fasciculations. All known ALS-linked SPTLC1 mutations cluster within exon 2 and a specific variant, c.58G>T, results in exon 2 skipping. However, it is unclear how the exon 2 deletion affects SPTLC1 function in vivo and contributes to ALS pathogenesis.

1 Introduction With the rapid expansion of urbanization, noise pollution has emerged as a significant social issue, posing threats to the global economy, ecological environment, and human health.[1, 2] An additional issue linked to urbanization is building-related pollution, characterized by high levels of carbon emissions and waste generation. The construction sector accounts for ≈40% of global energy consumption and almost 38% of total annual CO2 emissions.