Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Gary Shaw
PregMedNet: Multifaceted maternal medication impacts on neonatal complications
Abstract While medication use is common among pregnant women, medication safety remains insufficiently characterized because studies in pregnant women are challenging due to safety concerns. The recent digitization of healthcare databases and advances in computational methods have created new opportunities for large-scale, retrospective drug safety evaluations.
Single-cell spatiotemporal dissection of the human maternal–fetal interface
|
Abstract The human maternal–fetal interface is characterized by mosaic intermingling of maternal and fetal cells1. Yet the underlying cellular, molecular and spatial programmes remain incompletely defined.
By Cheng Wang, Yan Zhou, Yuejun Wang, Tuhin Guha, Tara McIntyre, Marisa E. Schwab, Brittany Davidson, Ronald Wong, Sarah England, Juan Gonzalez, Juan González Verified, Robert Blelloch, Alexis Combes, Linda Giudice, Adrian Erlebacher, Tippi MacKenzie, David Stevenson, Gary Shaw, Michael Snyder Verified, Xiaofei Sun, Virginia D. Winn, Susan Fisher, Jingjing Li, Zhida Luo, Anxhela Mustafaraj, Gabriella C. Reeder
|
Nature
Verified
Distinguishing syndromic and nonsyndromic cleft palate through analysis of protein-altering de novo variants in 818 trios
|
Keywords cleft palate variation phenotypic heterogeneity genetic architecture de novo Get full text access Log in, subscribe or purchase for full access. References 1. Mai, C.T. ∙ Isenburg, J.L. ∙ Canfield, M.A. ... National population-based estimates for major birth defects, 2010-2014 Birth Defects Res. 2019; 111:1420-1435 2. Stewart, J.M. ∙ Ott, J.E. ∙ Lagace, R. Submucous cleft palate: prevalence in a school population Cleft Palate J. 1972; 9:246-250 3. Kang, S.L. ∙ Narayanan, C.S. ∙ Kelsall, W.
By Kelsey Robinson, Sarah Curtis, Justin E. Paschall, Wasiu Lanre Adeyemo, Terri H Beaty, Azeez Butali, David Cutler, Michael Epstein, Jacqueline T. Hecht, Gary Shaw, Lina Uribe, Jeffrey C. Murray, Harrison A. Brand, Seth Weinberg, Mary L. Marazita, Kimberly Doheny, Elizabeth J. Leslie-Clarkson, Carmen J. Buxó, J.J. Gowans
|
The American Journal of Human Genetics
Verified
ARHGAP12 and ARHGAP29 exert distinct regulatory effects on switching between two cell morphological states through GSK-3 activity
|
Main reagents The GSK-3 inhibitor bromoindirubin-3-oxime (BIO) (Selleckchem, Ely, UK; cat # S7198) in DMSO was prepared as predetermined working dilutions (5 μM) in the appropriate culture medium. The multi-targeted Src kinase inhibitor Dasatinib (Selleckchem, Ely, UK; cat # S1021) in DMSO was also prepared as predetermined working dilution (10 μM) in the appropriate culture medium.
By Vinton Cheng, Philippa Vaughn-Beaucaire, Gary Shaw, Malte Kriegs, Alastair Droop, George Psakis, Michel Mittelbronn, Matt Humphries, Filomena Esteves, Josie Hayes, Julia V. Cockle, Sabine Knipp, Arndt Rohwedder, Azzam Ismail, Ola Rominiyi, Spencer J. Collis, Georgia Mavria, James Samarasekara, John E. Ladbury, Sophie Ketchen, Ruth Morton Verified, Sarah Fagan, Daniel Tams, Katie Myers Verified, Connor McGarrity-Cottrell, Mark J. Dunning, Marjorie Boissinot, George Michalopoulos, Sally Prior, Ewan Morrison, Susan Short, Sean E. Lawler, Anke Brüning-Richardson
|
Cell Reports
Verified
Sorting Circuit Split On Foreign Arbitration Treaty's Authority - Law360
Hello! I'm Law360's automated support bot. How can I help you today? For example, you can type: I forgot my password I took a free trial but didn't get a verification email How do I sign up for a newsletter?
USING FÖRSTER RESONANCE ENERGY TRANSFER (FRET) TO UNDERSTAND THE UBIQUITINATION LANDSCAPE
Förster resonance energy transfer (FRET) is a fluorescence technique that allows quantitative measurement of protein interactions, kinetics and dynamics. This review covers the use of FRET to study the structures and mechanisms of ubiquitination and related proteins. We survey FRET assays that have been developed where donor and acceptor fluorophores are placed on E1, E2 or E3 enzymes and ubiquitin (Ub) to monitor steady-state and real-time transfer of Ub through the ubiquitination cascade.
Happy Monday Friends!
Gary Shaw 11 <!tag blob="forumpost.visitstar"> Happy Monday Friends! Dec 04, 2023,20:18 PM A relatively recent pick up that has just recently returned from service. <!tag blob="addthis.follow.small"> Comments: view entire thread Happy Monday Friends! By: Gary Shaw : December 4th, 2023-20:18 A relatively recent pick up that has just recently returned from service. ...
2021 insurance industry outlook
In our 2021 insurance outlook, 200 industry leaders weighed in on their companies’ COVID-19 recovery efforts. How can the emerging lessons serve as a catalyst for business transformation? As new regulatory trends make an impact in the financial services marketplace, how can your organization remain resilient? Our 2021 regulatory outlooks explore key issues that could have a significant impact on the market and your business in 2021.
Potential implications of COVID-19 for the insurance sector
COVID-19 is impacting the insurance industry in multiple ways—from employee and business continuity issues to client service considerations to the financial outlook. Here are some key issues insurers face and potential action steps they could take. Insurers are responding to the widening COVID-19 outbreak on multiple fronts—as claims payers, employers, and capital managers. Each has its own distinct challenges, not just for the insurance industry, but for the economy and society at large.
Hewlett Packard Enterprise Rockets On Q1; Could It Reign In Cloud?
While investors applauded Hewlett Packard Enterprise's first quarterly performance as an independent company -- beating Wall Street estimates and driving its stock up more than 13% Friday -- some analysts and owners are pushing CEO Meg Whitman to compete harder. That means more aggressively taking on cloud enterprise leaders Amazon ( AMZN) and Microsoft ( MSFT), and buying up software rivals such as Workday ( WDAY) or Salesforce.com ( CRM), rather than directing cash to shareholders.
Where's Big Data In '16? Game Changing, Beyond Better | Stock News & Stock Market Analysis - IBD
Trying to identify which among the many enterprise software companies deserve the most attention in 2016 might be impossible, but we've cut our list down to six. Among cloud software upstarts, Splunk (SPLK), Tableau Software (DATA) and Qlik Technologies (QLIK) could make noise in the new year. And among the longtime standard-bearers, Hewlett Packard Enterprise (HPE), IBM (IBM) and Oracle (ORCL) bear watching.
Loxo Oncology Cancer Treatment And Research Takes 'Tumor Agnostic' Approach
The potential cancer-cure disclosures that propelled Loxo Oncology (LOXO) stock up 43% one day in June and an additional 15% one day in September indicate innovation in cancer research and treatment that many investors say could keep Loxo aloft. XAutoplay: On | OffWith a potential near-blockbuster cancer treatment in the making, Loxo is recognized by Investor's Business Daily in the inaugural IBD Biotech Innovators Awards.
Calcium-Mediated Control of S100 Proteins: Allosteric Communication via an Agitator/Signal Blocking Mechanism
Allosteric proteins possess dynamically coupled residues for the propagation of input signals to distant target binding sites. The input signals usually correspond to “effector is present” or “effector is not present”. Many aspects of allosteric regulation remain incompletely understood. This work focused on S100A11, a dimeric EF-hand protein with two hydrophobic target binding sites. An annexin peptide (Ax) served as the target.
RBR Ubiquitin Transfer: Not Simply an “Open” and “Closed” Case?
Now available: purchase access to all research journal HTML articles for 6 or 24 hours. Click here to explore this opportunity. If you are a current subscriber with Society Membership or an Account Number, claim your access now. Purchase a subscription to gain access to this and all other articles in this journal.
Preterm Birth as a Calendar Event or Immunologic Anomaly
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Juniper Stock Yields To Softer Q1 Performance, Despite '16 Optimism
Click to email this to a friend (Opens in new window) The thrill of Juniper Networks (JNPR) management’s optimism, despite their Q2 guidance miss, seemed to wear thin on investors who started Friday with a 2.6% pop but watched their stock deflate all day along with the overall stock market. After Thursday’s close, Juniper, the biggest computer networking rival of No. 1 Cisco Systems (CSCO), disclosed refined first-quarter earnings and revenue growth that missed initial guidance.
AbbVie To Pay $5.8 Bil And Milestones For Stemcentrx, Diluting EPS
Click to email this to a friend (Opens in new window) AbbVie (ABBV) says that four years will pass before it begins to accrete earnings from its $5.8 billion purchase of Stemcentrx, but AbbVie stock reversed an early loss and was up early Thursday afternoon after the companies announced the acquisition. AbbVie stock fell as much as 5.2% early in the stock market today, but it was up a fraction, near 61, in afternoon trading, 15% off a record high of 71.60 set July 21.
Ultimate Software Gains Momentum, Beats Street, Raises Forecast
Click to email this to a friend (Opens in new window) Shares of enterprise software maker Ultimate Software Group (ULTI) jumped 6% in morning trade before settling back, following Tuesday’s impressive first-quarter report, which beat Wall Street’s top and bottom lines.
Cloud Computing Not Seen Cannibalizing Server Market, As Assumed
Dell owner Michael Dell as well as investors in Hewlett Packard Enterprise (HPE) and IBM (IBM) — the big 3 computer server companies — ought to appreciate Bernstein’s latest take on how much the cloud is cannibalizing the server market. It’s not, says the investment bank. “Isn’t it unbelievable?” chided Bernstein analyst Pierre Ferragu in a Friday research note re-issued Tuesday.
Netgear Finds Better Profit Focusing On Home Routers, IoT, Not ISPs
Higher profit on lower revenue? Investors expecting greater efficiency out of home Wi-Fi networker Netgear (NTGR) likely won’t be disappointed after the close Wednesday. That’s when Wall Street expects Netgear to report that first-quarter earnings rose 30%, which would be its best showing in 17 quarters, while a decline in low-margin Internet service provider (ISP) gear might have led total sales to a 3.5% decline.
Insurance Industry Outlook 2016
Many insurance companies are facing existential challenges to the foundation of their value proposition. Among them are rising customer expectations for personalized products and services in an increasingly connected world, macro-shifts in the economy and culture that threaten to dismantle their traditional business models, as well as new categories of exposures that offer both growth opportunities and inherent bottom-line risks.
Xerox Stock Rebuilds; Q1 EPS Rise Expected, But Not Better Revenue
Click to email this to a friend (Opens in new window) Take your eye off iconic copier maker Xerox (XRX) for too long — heck, Xerox stock had done little more than fall since December 2014 — and you would have missed its run-up to Tuesday’s eight-month high at 11.39, up 34% since touching a nearly three-year low in January at 8.48. Xerox stock closed Friday at 11.16, flat for the session.
Citrix Stock Hits High On Strong Q1 Pace; Not Everyone Raises PT
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) After Citrix Systems (CTXS) beat Wall Street’s Q1 forecast — and raised its full-year outlook — investors sent Citrix stock flying as much 12% higher Thursday to 90, a 16-year high.
ServiceNow Stock Jump Puts Software Slump Mostly In The Dump
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Realizing that more big customers than ever are paying bigger dollars for ServiceNow (NOW) software in the cloud, investors bought up ServiceNow stock Thursday, healing much of the pain that they endured through the infamous Software Slump of...
VMware Cloud Business Lifts Q2 Outlook Above Expectations; Stock Up
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Investors rushed to buy VMware (VMW) shares early in the stock market today, driving the price up 14% to a four-month high above 59, after the virtualization software leader raised its guidance late Tuesday.
Citrix Grows EPS, Sales Faster Than Modeled After Reorganization
Click to email this to a friend (Opens in new window) Apparently not too distracted by its reorganization, the highest-rated issue in IBD’s Computer Software-Specialty Enterprise industry group, Citrix Systems (CTXS) boosted its Q1 earnings faster than analysts had expected. Reporting after the market close, the maker of cloud management software said Q1 adjusted earnings rose 81% to $1.18 per share, where Wall Street expected 92 cents.
Manhattan Associates Beats Street, Raises Guidance As Stock Jumps
Click to print (Opens in new window) Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Supply chain software developer Manhattan Associates (MANH) beat Wall Street’s first-quarter earnings and revenues estimates, then raised its full-year 2016 guidance after the market close Tuesday.
Optics Benefit First From Microsoft, Amazon, Google Cloud Growth
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) You might think the race to the cloud mostly benefits leading cloud services providers, such as Microsoft (MSFT), Amazon.com (AMZN) and Alphabet‘s (GOOGL) Google.
No Slouch, But Manhattan Associates' EPS Growth May Have Eased To 15%
Investors are hoping fast-growing supply-chain software developer Manhattan Associates (MANH) will say something Tuesday to help re-accelerate growth. Not that Manhattan is any slouch, but the 15% improvement in first-quarter earnings that it’s expected to disclose after Tuesday’s market close would be its slowest year-to-year growth rate in 15 quarters. Six of those 15 quarters have topped 30% earnings growth, including Q3 and Q4 2015, and all but two of the last 15 topped 20%.
Super Micro Computer Drops Q3 Estimates; Investors Drop Stock
Click to email this to a friend (Opens in new window) Highly rated small cap Super Micro Computer (SMCI) lowered its third-quarter estimates after the close Thursday and then watched its stock crash Friday. Super Micro stock plunged nearly 19% in heavy afternoon trading in the stock market today, near 27. The stock had made a breakout at 33.89 from a cup-with-handle base, but that breakout has now failed.
ServiceNow Settles Patent Cases With BMC, HPE, Taking $270 Mil Bite
Workflow software developer ServiceNow (NOW) lightened its wallet by $270 million, then lightened its stock price Thursday. ServiceNow stock stumbled 3% after the bell in the stock market today before recovering. It was down a fraction, above 63, in afternoon trading Thursday, 30% off its record high of 91.28, set Dec. 4. ServiceNow went public in December 2012 at 18.
Infosys' 2017 Outlook May Impress Wall Street More Than Q4 Improvement
Wall Street seems to be more interested in what the Indian outsourcing companies will do next than how they performed previously. No surprises are expected when one of the biggest, Infosys (INFY), reports its fiscal 2016 fourth-quarter earnings way after the close Thursday, scheduled for 11:45 p.m. ET — or about 9:15 a.m. Friday in Bangalore.
Cisco Targets Cybersecurity For Productivity, Not Just Defense
Click to email this to a friend (Opens in new window) Cisco Systems (CSCO) wants organizational leaders to understand that improving their competitive advantage, not just responding to fear, should inspire their cybersecurity strategy. Fearful tales, however, are hard to ignore.
Juniper's Q1 Miss Drags Down Networking Stocks; Chips Fall Too
When enterprise clients slow down purchases, and Internet service providers delay capital expenditures, Juniper Networks (JNPR) has a problem. The top computer-networking gear maker not named Cisco Systems (CSCO) pre-announced just such a first-quarter situation after the market close Monday, sending networking stocks lower Tuesday. Juniper stock fell 7.4%, to 23.06, in the stock market today, as at least three investment banks lowered their price target. Cisco stock was flat.
SAP's Q1 Misses, But Strong Pipeline Into Q2 Keeps Stock Near High
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) While SAP (SAP) late Friday preannounced Q1 earnings and revenue that missed Wall Street views, investors Monday were buoyed by the German enterprise software company’s assurances that its pipeline is flowing strongly into Q2.
Ciena Gets A 'Buy' Rating Affirmation After Alliance Gets A Buyer
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Competing in the shadow of Cisco Systems (CSCO) can be a tough place for Ciena (CIEN), the specialty fiber optics developer for telecom and cable service providers: Perform inadequately and you’re dust. Perform well and get picked off.
Oracle Cloud Should 'More Than Offset' Slip In New Licenses In '17
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) With a chance to chat with Oracle (ORCL) customers during its Chicago trade show that ends Thursday, Evercore ISI analyst Kirk Materne came away more convinced that the legacy software leader has its head in the fast-growing cloud.
Cerner Swapping Siemens Software For Millennium At Universal Health
Click to email this to a friend (Opens in new window) One way to win a big contract is to persuade existing customers to buy your companion products. Another way to win is to buy your rival and sell your products to your ex-rival’s customers.
Cisco Upgraded As JPMorgan Firms Up Q3's 14th Week Sales Estimate
Click to email this to a friend (Opens in new window) With a 14th week in its current third fiscal quarter and apparently enough momentum to hit 2016 consensus even if its switching business continues to weaken, Cisco Systems (CSCO) earned an upgrade from JPMorgan Wednesday. JPMorgan analyst Rod Hall used a proprietary statistical model suggesting “limited downside” for the world’s most essential computer networking gear maker, assuming 2.5% global GDP growth in 2016.
Palo Alto Networks Stock Falls After Analyst Day As Price Targets Change
Click to email this to a friend (Opens in new window) Palo Alto Networks (PANW) hosted an upbeat Analysts Day at its Ignite 2016 cybersecurity conference in Las Vegas Monday, but the stock erased weeks of gain Tuesday. It’s still up 39% from a low point on Feb. 8. The biggest pure-play computer network security company fell 6% to 151.92 in the stock market today. The drop reflected its worst day since a 7.2% slide on Feb. 18 in the throes of the January-February software sag of 2016.
Brocade Stock Dives While Raising Ruckus Over Networking Merger
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Computer networking midcap Brocade Communications Systems (BRCD) said Monday it’s agreed to acquire small-cap mobile networker Ruckus Wireless (RKUS) for $1.5 billion, sending Ruckus stock soaring 32%, as of midday, while Brocade stock plunged 14%.
Workday May Hit $5 Bil In 5 Years As Financial Software Kicks In
Click to email this to a friend (Opens in new window) At the rate Workday (WDAY) is growing its core human capital management (HCM) software, combined with its new financial management products, analysts Ross MacMillan and Matthew Hedberg can see Workday’s path to $5 billion in yearly sales by 2021. The company just hit it first billion-dollar year, closing its fiscal year ended Jan. 31 with sales of $1.16 billion.
Cognizant Nears, ExlService Hits Record As Outsourcing Stocks Rise
You can almost hear the conversation: “That team did such a great job on that project,” said CEO Joe Fiction, “let’s give them the entire product line to operate and save some dough.” Converting traditional business process outsourcing (BPO) into business process management (BPM) framed the Indo-U.S. BPO Summit this week in Orlando, Fla., sponsored by the Indo-American Chamber of Commerce and India’s National Association of Software and Services Companies (NASSCOM).
Workday Financial Software Heading For 'Success'; Stock Gains Again
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Building momentum from a week of positive trade, cloud software developer Workday’s (WDAY) stock gained another 1% Friday morning — nearly 8% for the week — after FBR Capital Markets satisfied itself that Workday’s financial software may “achieve...
Salesforce.com Gets A Nod From IBM, Investors Like Fed Deal More
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Nothing quite like a BPA — blanket purchase agreement — from the federal government to pick up your Wednesday.
Allscripts Lands A Deal; Cerner Faces Security Challenge At MedStar
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Allscripts Healthcare Solutions (MDRX) stock jumped again Wednesday, with Wall Street “extremely encouraged” by a deal to extend Allscripts’ information tech to University Hospitals in northeast Ohio through 2024.
Oracle Seeks $9.3 Bil From Google Over Java Use; Trial Nears
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) Oracle (ORCL) stock slipped nearly 1% and Alphabet (GOOGL) stalled flat following a report that Oracle will seek as much as $9.3 billion in damages from Google Android’s use of Oracle’s iconic Java software.
Zendesk Attracting Larger Customers For Its Business Software
Click to email this to a friend (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Google+ (Opens in new window) Click to share on Twitter (Opens in new window) When you’re “a small player in a large market that is still new, fragmented and growing,” a key to success is “staying one step ahead of the competition,” and that’s what workplace software developer Zendesk (ZEN) is doing, said Summit Research analyst Jonathan Kees.
Accenture Rides Clients' Disruption Avoidance; Stock Rides New High
Click to email this to a friend (Opens in new window) Shares of Accenture, the tech outsourcing and consulting company, jumped to a record high Thursday after the company reported a 24% improvement in fiscal second-quarter earnings, well beyond what Wall Street expected. It also beat revenue estimates. The company also raised its earnings guidance for the fiscal year ending in August.
Accenture Survives Software Sag Of '16, Stock Flirts With Record
Click to email this to a friend (Opens in new window) Seemingly fully recovered from the infamous Software Sag of 2016 in January and February, big-cap Accenture (ACN) is flirting with a record-high stock price amid growth in its services, as it heads towards its fiscal Q2 earnings release due before the market open Thursday. Accenture stock was down a fraction in early trading in the stock market today, near 108, 18% above its seven-month low of 91.40 touched on Feb.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Gary
Contact Gary, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack