George Chapman

Abstract Dopamine D2/D3 receptor modulation with antipsychotics is thought to affect cognitive function, but causal evidence in humans is scant, and largely limited to single administrations. Clarifying this is of importance given the widespread use of antipsychotics, and to understand the role of D2/D3 signalling in human cognition.

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Stately home On arriving at Wilton House to meet Lord Pembroke, our instructions to reach the house are to drive through a large children’s adventure playground. While this might seem at odds with the beauty and grandeur of Wiltshire’s and indeed one of England’s finest and most original stately homes, on meeting Lord Pembroke, it makes perfect sense – the property is first and foremost a fully operational family home that's also open to the public.