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George Stephen Kelly on Muck Rack

George Stephen Kelly

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Articles

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule

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By George Stephen Kelly, Tetsushi Kataura, Johan Panek, Gailing Ma, Ashley Davis, Hannah Kendall, Charlotte Brookes, Peter Banks, Glyn Nelson, Patricia R. Pitrez, Laura Booth, Gailing Ma, Hanna Salmonowicz, Daniel Moscoh Ayine-Tora, Laura Dobby, Lydia Costello, Gavin D. Richard
| Cell Press Verified
Highlights • Basal mitophagy is highly active in various primary human cells in culture • PINK1, Parkin, and p62 are essential for basal mitophagy in primary fibroblasts • Loss of mitophagy drives cellular senescence phenotypes and is evident in aging • Mitophagy activators rescue senescence/aging-related changes in cell function Summary Selective degradation of damaged mitochondria by autophagy (mitophagy) is proposed to play an important role in cellular homeostasis.
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