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Gerrald A. Lodewijk on Muck Rack

Gerrald A. Lodewijk

As seen in: BioRxiv, Cell Press, Cell Stem Cell
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Articles

Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming

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By Gerrald A. Lodewijk, Sayaka Kozuki, Clara Han, Benjamin R. Topacio, Seungho Lee, Abolfazl Zargari, Gavin Knight, Lei Qi, S. Shariati, Lily Nixon, Randolph Ashton
| Cell Stem Cell Verified
Keywords embryo models Collective Motion embryonic patterning epigenome editing CRISPRa synthetic biology Introduction New frontiers are emerging in the study of mammalian embryogenesis through engineering stem cell-based embryo models (SEMs) using the unrestricted potential of embryonic stem cells (ESCs) and their self-organizing behavior.1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26 SEMs can reproduce key aspects of spatial organization of pre- and post-gastrulation...
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Self-organization of embryonic stem cells into a reproducible embryo model through epigenome editing

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By Gerrald A. Lodewijk, Benjamin R. Topacio, Sayaka Kozuki, Clara Han
| BioRxiv
Abstract Embryonic stem cells (ESCs) can self-organize in vitro into developmental patterns with spatial organization and molecular similarity to that of early embryonic stages. This self-organization of ESCs requires transmission of signaling cues, via addition of small molecule chemicals or recombinant proteins, to induce distinct embryonic cellular fates and subsequent assembly into structures that can mimic aspects of early embryonic development.
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The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles

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By Michael Coulter, Gerrald A. Lodewijk, Cristina M. Dorobantu
| Cell Press Verified
Chmp1a Is Expressed in Postmitotic Neurons and Choroid Plexus during Brain Development   Many Potential EV Functions in the CNS Chmp1a Is Expressed in Postmitotic Neurons and Choroid Plexus during Brain Development   Many Potential EV Functions in the CNS Matching coronal telencephalon sections at E12.5 or E14.5, or midline sagittal cerebellum sections at P0 were immunostained for pH3.
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